Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
Samo za registrovane korisnike
2018
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a l...ot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
Ključne reči:
Composite hydrogel membrane Crosslinker Ion exchange Diffusion Iontophoresis Drug releaseIzvor:
Polymer, 2018, 147, 56-66Izdavač:
- Elsevier
Finansiranje / projekti:
- Mikro, nano-sistemi i senzori za primenu u elektroprivredi, procesnoj industriji i zaštiti životne sredine (RS-MESTD-Technological Development (TD or TR)-32008)
Napomena:
- Supplementary information: https://hdl.handle.net/21.15107/rcub_dais_3392
- Peer-reviewed manuscript: https://hdl.handle.net/21.15107/rcub_dais_4526
Povezane informacije:
- Druga verzija
https://hdl.handle.net/21.15107/rcub_dais_4526 - Povezani sadržaj
https://hdl.handle.net/21.15107/rcub_dais_3392
DOI: 10.1016/j.polymer.2018.05.065
ISSN: 0032-3861
WoS: 000436484100007
Scopus: 2-s2.0-85048491046
Institucija/grupa
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Janićijević, Željko AU - Radovanović, Filip PY - 2018 UR - https://dais.sanu.ac.rs/123456789/3391 AB - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes performed by combining photoirradiation with a traditional liquid phase inversion process. Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and 75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker were investigated in vitro using methylene blue as a model drug. Passive release kinetics was diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs. PB - Elsevier T2 - Polymer T1 - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations SP - 56 EP - 66 VL - 147 DO - 10.1016/j.polymer.2018.05.065 UR - https://hdl.handle.net/21.15107/rcub_dais_3391 ER -
@article{ author = "Janićijević, Željko and Radovanović, Filip", year = "2018", abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes performed by combining photoirradiation with a traditional liquid phase inversion process. Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and 75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker were investigated in vitro using methylene blue as a model drug. Passive release kinetics was diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.", publisher = "Elsevier", journal = "Polymer", title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations", pages = "56-66", volume = "147", doi = "10.1016/j.polymer.2018.05.065", url = "https://hdl.handle.net/21.15107/rcub_dais_3391" }
Janićijević, Ž.,& Radovanović, F.. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer Elsevier., 147, 56-66. https://doi.org/10.1016/j.polymer.2018.05.065 https://hdl.handle.net/21.15107/rcub_dais_3391
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer. 2018;147:56-66. doi:10.1016/j.polymer.2018.05.065 https://hdl.handle.net/21.15107/rcub_dais_3391 .
Janićijević, Željko, Radovanović, Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" in Polymer, 147 (2018):56-66, https://doi.org/10.1016/j.polymer.2018.05.065 ., https://hdl.handle.net/21.15107/rcub_dais_3391 .