Green synthesis of PGA-capped silver nanoparticles and their characterization

Abstract

Owing to their persistent antibacterial properties, Ag nanoparticles are increasingly used in clinical practice and investigated in recent laboratory research. Although there are a number of methods for the synthesis of Ag nanoparticles, recent research trends comply with the requirements of Non-toxic Environmental Chemistry. In this study, the synthesis of silver nanoparticles was based on the principles of green chemistry. In order to improve their antibacterial properties and biocompatibility, Ag nanoparticles can be coated with various biocompatible and biodegradable polymers that can ensure their better interaction with cells and more favourable size distribution. Poly(α, γ-glutamic acid) is one of the polymers that have the required properties; it also serves as particle stabilizer. The synthesis of Ag nanoparticles was performed by a modified chemical reduction method with glucose as the reducing agent. The samples were characterized by UV/ Vis spectroscopy, FESEM and Zeta potential measurements