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Thermal crystallization of amorphous calcium phosphate combined with citrate and fluoride doping: a novel route to produce hydroxyapatite bioceramics
dc.creator | Degli Esposti, Lorenzo | |
dc.creator | Marković, Smilja | |
dc.creator | Ignjatović, Nenad | |
dc.creator | Panseri, Silvia | |
dc.creator | Montesi, Monica | |
dc.creator | Adamiano, Alessio | |
dc.creator | Fosca, Marco | |
dc.creator | Rau, Julietta V. | |
dc.creator | Uskoković, Vuk | |
dc.creator | Iafisco, Michele | |
dc.date.accessioned | 2021-06-24T10:20:56Z | |
dc.date.available | 2021-06-24T10:20:56Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2050-750X | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.uri | https://dais.sanu.ac.rs/123456789/11639 | |
dc.description.abstract | Amorphous calcium phosphate (ACP) is a material of high interest for dentistry, orthopedics, and other biomedical sectors. Being intrinsically metastable, the process of transformation of ACP into a crystalline phase upon heating is of high relevance for the development of innovative bioceramics. Here we have first studied the thermal behavior of a citrate-stabilized ACP (Cit-ACP) also doped with fluoride ions (Cit-FACP) prepared at three different nominal Cit/Ca ratios (i.e. 4, 2, 1) by differential thermal analysis. Next, the physico-chemical features of the crystalline products as well as the in vitro cell response to the materials were investigated. A citrate and fluoride free ACP sample was also tested as the blank. We have found that the activation energy of crystallization of Cit-(F)ACP samples is lower in comparison to the blank ACP and this is influenced by the nominal Cit/Ca molar ratio. Interestingly, we have discovered that the thermal treatment of Cit-(F)ACP at 800 °C yields hydroxyapatite (HA) or fluorapatite (FHA) as the main products differently from blank ACP that, like most of the ACPs reported in the literature, yields β-tricalcium phosphate. This was attributed to the Ca/P ratio of Cit-(F)ACP, which is similar to HA. A study of the crystalline products has revealed that all the (F)HA samples were non-cytotoxic, and retained carbonate ions in the crystal structure despite the heat treatment that should have induced decarbonation. The morphology of the products is influenced by the nominal Cit/Ca ratio and the presence of fluoride, ranging from spherical nanoparticles to micrometric hexagonal rods. Overall, our results prove that the thermal crystallization of Cit-(F)ACP is markedly different from classic ACP based materials and the thermal treatment of Cit-(F)ACP represents an attractive route for producing pure bioactive HA ceramics. | |
dc.publisher | Royal Society of Chemistry | en |
dc.relation | Ministry of Health (Bando Ricerca Finalizzata 2016, no. GR-2016-02364704) | |
dc.relation.isversionof | https://hdl.handle.net/21.15107/rcub_dais_11640 | |
dc.relation.isreferencedby | https://hdl.handle.net/21.15107/rcub_dais_11642 | |
dc.rights | restrictedAccess | |
dc.source | Journal of Materials Chemistry B | en |
dc.subject | calcium phosphate | |
dc.subject | amorphous materials | |
dc.subject | doping | |
dc.subject | citrate | |
dc.subject | fluoride | |
dc.subject | hydroxyapatite | |
dc.subject | bioceramics | |
dc.title | Thermal crystallization of amorphous calcium phosphate combined with citrate and fluoride doping: a novel route to produce hydroxyapatite bioceramics | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Марковић, Смиља; Игњатовић, Ненад; Ускоковић, Вук; Aдамиано, Aлессио; Фосца, Марцо; Рау, Јулиетта В.; Иафисцо, Мицхеле; Монтеси, Моница; Дегли Еспости, Лорензо; Пансери, Силвиа; | |
dc.citation.spage | 4832 | |
dc.citation.epage | 4845 | |
dc.citation.volume | 9 | |
dc.citation.issue | 24 | |
dc.identifier.wos | 000651135000001 | |
dc.identifier.doi | 10.1039/D1TB00601K | |
dc.description.other | Peer-reviewed manuscript: [https://hdl.handle.net/21.15107/rcub_dais_11640] | |
dc.description.other | Supplementary information: [https://hdl.handle.net/21.15107/rcub_dais_11642] | |
dc.type.version | publishedVersion | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_dais_11639 |