Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles
Samo za registrovane korisnike
2013
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Abstract
Objectives
The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery.
Methods
Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland).
Key findings
The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen re...lease that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time.
Conclusions
Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen.
Ključne reči:
ketoprofen / microneedles / nanoparticles / skinIzvor:
Journal of Pharmacy and Pharmacology, 2013, 65, 10, 1451-1462Izdavač:
- Hoboken, NJ : John Wiley & Sons
Finansiranje / projekti:
- Molekularno dizajniranje nanočestica kontrolisanih morfoloških i fizičko-hemijskih karakteristika i funkcionalnih materijala na njihovoj osnovi (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-MESTD-Technological Development (TD or TR)-34031)
DOI: 10.1111/jphp.12118
ISSN: 0022-3573 (Print); 2042-7158
WoS: 000324017600003
Scopus: 2-s2.0-84883741603
Institucija/grupa
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Vučen, Sonja AU - Vuleta, Gordana AU - Crean, Abina AU - Moore, Anne C. AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2013 UR - https://dais.sanu.ac.rs/123456789/383 AB - Abstract Objectives The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery. Methods Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland). Key findings The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time. Conclusions Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen. PB - Hoboken, NJ : John Wiley & Sons T2 - Journal of Pharmacy and Pharmacology T1 - Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles SP - 1451 EP - 1462 VL - 65 IS - 10 DO - 10.1111/jphp.12118 UR - https://hdl.handle.net/21.15107/rcub_dais_383 ER -
@article{ author = "Vučen, Sonja and Vuleta, Gordana and Crean, Abina and Moore, Anne C. and Ignjatović, Nenad and Uskoković, Dragan", year = "2013", abstract = "Abstract Objectives The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery. Methods Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland). Key findings The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time. Conclusions Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen.", publisher = "Hoboken, NJ : John Wiley & Sons", journal = "Journal of Pharmacy and Pharmacology", title = "Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles", pages = "1451-1462", volume = "65", number = "10", doi = "10.1111/jphp.12118", url = "https://hdl.handle.net/21.15107/rcub_dais_383" }
Vučen, S., Vuleta, G., Crean, A., Moore, A. C., Ignjatović, N.,& Uskoković, D.. (2013). Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. in Journal of Pharmacy and Pharmacology Hoboken, NJ : John Wiley & Sons., 65(10), 1451-1462. https://doi.org/10.1111/jphp.12118 https://hdl.handle.net/21.15107/rcub_dais_383
Vučen S, Vuleta G, Crean A, Moore AC, Ignjatović N, Uskoković D. Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. in Journal of Pharmacy and Pharmacology. 2013;65(10):1451-1462. doi:10.1111/jphp.12118 https://hdl.handle.net/21.15107/rcub_dais_383 .
Vučen, Sonja, Vuleta, Gordana, Crean, Abina, Moore, Anne C., Ignjatović, Nenad, Uskoković, Dragan, "Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles" in Journal of Pharmacy and Pharmacology, 65, no. 10 (2013):1451-1462, https://doi.org/10.1111/jphp.12118 ., https://hdl.handle.net/21.15107/rcub_dais_383 .