Testing the antimicrobial activity of hydroxyapatite nanoparticles in vitro

Abstract

Antimicrobial materials based on hydroxyapatite are very attractive for wide application in medicine and stomatology. The goal of this work was to test antimicrobial activity of hydroxyapatite nanoparticles Co/Ca- hydroxyapatite and biphasic calcium phosphate/ poly (lactide-co-glycolide) composite biomaterial. Antimicrobial activity of the samples was tested using dilution method and disk diffusion. The results of antimicrobial tests were obtained by determining the reduction percentage the number of bacteria in physiological solution where bacteria cells were exposed to the samples. It can be concluded that synthesized HAp biomaterials have satisfactory antimicrobial activity against tested bacteria strains.