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dc.creatorKostić, Ivana T.
dc.creatorIlić, Vesna Lj.
dc.creatorBukara, Katarina M.
dc.creatorMojsilović, Slavko B.
dc.creatorĐurić, Zorka Ž.
dc.creatorDraškovič, Petra
dc.creatorBugarski, Branko M.
dc.date.accessioned2018-07-25T12:25:53Z
dc.date.available2018-07-25T12:25:53Z
dc.date.issued2015
dc.identifier.issn0367-598X (Print)
dc.identifier.issn2217-7426 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3533
dc.description.abstractDespite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitates the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of porcine erythrocytes, it indicated the differences in porcine erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected. © 2015, Association of Chemists and Chemical Engineers of Serbia. All rights reserved.
dc.publisherBelgrade: Association of the Chemical Engineers of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationBilateral cooperation program between the Republic of Serbia and the Republic of Slovenia, 2012–2013
dc.rightsopenAccess
dc.sourceHemijska Industrija
dc.subjecterythrocytes
dc.subjectflow cytometry
dc.subjectmechanical fragility
dc.subjectmicrocytic anaemia
dc.subjectosmotic fragility
dc.subjectosmotic swelling
dc.titleFlow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractИлић, Весна Љ.; Костић, Ивана Т.; Букара, Катарина М.; Мојсиловић, Славко Б.; Ђурић, Зорка Ж.; Драшкович, Петра; Бугарски, Бранко М.;
dc.citation.spage67
dc.citation.epage76
dc.citation.volume69
dc.citation.issue1
dc.identifier.wos000350913100009
dc.identifier.doi10.2298/HEMIND140124021K
dc.identifier.scopus2-s2.0-84923652588
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/handle/123456789/3533/Kostic_2015_Hemijska-Industrija_69_67.pdf


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