dc.creator | Janićijević, Željko | |
dc.creator | Radovanović, Filip | |
dc.date.accessioned | 2018-06-15T09:00:55Z | |
dc.date.available | 2018-06-15T09:00:55Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0032-3861 | |
dc.identifier.uri | https://dais.sanu.ac.rs/123456789/3391 | |
dc.description.abstract | We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/32008/RS// | sr |
dc.relation.isversionof | https://hdl.handle.net/21.15107/rcub_dais_4526 | |
dc.relation.isreferencedby | https://hdl.handle.net/21.15107/rcub_dais_3392 | |
dc.rights | restrictedAccess | sr |
dc.source | Polymer | sr |
dc.subject | Composite hydrogel membrane Crosslinker Ion exchange Diffusion Iontophoresis Drug release | sr |
dc.title | Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Јанићијевић, Жељко; Радовановић, Филип; | |
dc.citation.spage | 56 | |
dc.citation.epage | 66 | |
dc.citation.volume | 147 | |
dc.identifier.wos | 000436484100007 | |
dc.identifier.doi | 10.1016/j.polymer.2018.05.065 | |
dc.identifier.scopus | 2-s2.0-85048491046 | |
dc.description.other | Supplementary information: [https://hdl.handle.net/21.15107/rcub_dais_3392] | |
dc.description.other | Peer-reviewed manuscript: [https://hdl.handle.net/21.15107/rcub_dais_4526] | |
dc.type.version | publishedVersion | sr |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_dais_3391 | |