Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity
Samo za registrovane korisnike
2019
Autori
Veljović, ĐorđeMatić, Tamara
Stamenić, Tanja
Kojić, Vesna
Dimitrijević Branković, Suzana
Lukić, Miodrag J.
Jevtić, Sanja
Radovanović, Željko
Petrović, Rada
Janaćković, Đorđe
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750–1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to β−tricalcium phosphate phase (β−TCP), which enabled formation of biphasic HAP/β−TCP and pure β−TCP phase at 160 °C during hydrothermal synthesis. In v...itro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m1/2 respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or β-TCP ceramics reported thus far.
Ključne reči:
biomedical application / hydroxyapatite / mechanical properties / sinteringIzvor:
Ceramics International, 2019, 45, 17, Part A, 22029-Izdavač:
- Elsevier
Finansiranje / projekti:
- Sinteza, razvoj tehnologija dobijanja i primena nanostrukturnih multifunkcionalnih materijala definisanih svojstava (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
Napomena:
- Peer-reviewed manuscript: https://hdl.handle.net/21.15107/rcub_dais_6504
Povezane informacije:
- Druga verzija
https://hdl.handle.net/21.15107/rcub_dais_6504
DOI: 10.1016/j.ceramint.2019.07.219
ISSN: 0272-8842
WoS: 000493212500122
Scopus: 2-s2.0-85069563982
URI
http://www.sciencedirect.com/science/article/pii/S0272884219320413https://dais.sanu.ac.rs/123456789/6948
Institucija/grupa
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Veljović, Đorđe AU - Matić, Tamara AU - Stamenić, Tanja AU - Kojić, Vesna AU - Dimitrijević Branković, Suzana AU - Lukić, Miodrag J. AU - Jevtić, Sanja AU - Radovanović, Željko AU - Petrović, Rada AU - Janaćković, Đorđe PY - 2019 UR - http://www.sciencedirect.com/science/article/pii/S0272884219320413 UR - https://dais.sanu.ac.rs/123456789/6948 AB - The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750–1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to β−tricalcium phosphate phase (β−TCP), which enabled formation of biphasic HAP/β−TCP and pure β−TCP phase at 160 °C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m1/2 respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or β-TCP ceramics reported thus far. PB - Elsevier T2 - Ceramics International T1 - Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity SP - 22029 SP - 22039 VL - 45 IS - 17, Part A DO - 10.1016/j.ceramint.2019.07.219 UR - https://hdl.handle.net/21.15107/rcub_dais_6948 ER -
@article{ author = "Veljović, Đorđe and Matić, Tamara and Stamenić, Tanja and Kojić, Vesna and Dimitrijević Branković, Suzana and Lukić, Miodrag J. and Jevtić, Sanja and Radovanović, Željko and Petrović, Rada and Janaćković, Đorđe", year = "2019", abstract = "The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750–1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to β−tricalcium phosphate phase (β−TCP), which enabled formation of biphasic HAP/β−TCP and pure β−TCP phase at 160 °C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m1/2 respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or β-TCP ceramics reported thus far.", publisher = "Elsevier", journal = "Ceramics International", title = "Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity", pages = "22029-22039", volume = "45", number = "17, Part A", doi = "10.1016/j.ceramint.2019.07.219", url = "https://hdl.handle.net/21.15107/rcub_dais_6948" }
Veljović, Đ., Matić, T., Stamenić, T., Kojić, V., Dimitrijević Branković, S., Lukić, M. J., Jevtić, S., Radovanović, Ž., Petrović, R.,& Janaćković, Đ.. (2019). Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International Elsevier., 45(17, Part A), 22029. https://doi.org/10.1016/j.ceramint.2019.07.219 https://hdl.handle.net/21.15107/rcub_dais_6948
Veljović Đ, Matić T, Stamenić T, Kojić V, Dimitrijević Branković S, Lukić MJ, Jevtić S, Radovanović Ž, Petrović R, Janaćković Đ. Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International. 2019;45(17, Part A):22029. doi:10.1016/j.ceramint.2019.07.219 https://hdl.handle.net/21.15107/rcub_dais_6948 .
Veljović, Đorđe, Matić, Tamara, Stamenić, Tanja, Kojić, Vesna, Dimitrijević Branković, Suzana, Lukić, Miodrag J., Jevtić, Sanja, Radovanović, Željko, Petrović, Rada, Janaćković, Đorđe, "Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity" in Ceramics International, 45, no. 17, Part A (2019):22029, https://doi.org/10.1016/j.ceramint.2019.07.219 ., https://hdl.handle.net/21.15107/rcub_dais_6948 .