Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality
2014
Аутори
Stevanović, MagdalenaNunić, Jana
Choi, Jonghoon
Filipović, Miloš
Uskoković, Dragan
Tsotakos, Theodore
Fragogeorgi, Eirini
Psimadas, Dimitris
Palamaris, Lazaros
Loudos, George
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparti...cles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.
Кључне речи:
selenium nanoparticles / poly (DL-lactide-co-glycolide) / anticancer activityИзвор:
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts, 2014, 38-38Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Stevanović, Magdalena AU - Nunić, Jana AU - Choi, Jonghoon AU - Filipović, Miloš AU - Uskoković, Dragan AU - Tsotakos, Theodore AU - Fragogeorgi, Eirini AU - Psimadas, Dimitris AU - Palamaris, Lazaros AU - Loudos, George PY - 2014 UR - https://dais.sanu.ac.rs/123456789/584 AB - Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen. PB - Belgrade : Materials Research Society of Serbia C3 - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts T1 - Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality SP - 38 EP - 38 UR - https://hdl.handle.net/21.15107/rcub_dais_584 ER -
@conference{ author = "Stevanović, Magdalena and Nunić, Jana and Choi, Jonghoon and Filipović, Miloš and Uskoković, Dragan and Tsotakos, Theodore and Fragogeorgi, Eirini and Psimadas, Dimitris and Palamaris, Lazaros and Loudos, George", year = "2014", abstract = "Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts", title = "Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality", pages = "38-38", url = "https://hdl.handle.net/21.15107/rcub_dais_584" }
Stevanović, M., Nunić, J., Choi, J., Filipović, M., Uskoković, D., Tsotakos, T., Fragogeorgi, E., Psimadas, D., Palamaris, L.,& Loudos, G.. (2014). Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 38-38. https://hdl.handle.net/21.15107/rcub_dais_584
Stevanović M, Nunić J, Choi J, Filipović M, Uskoković D, Tsotakos T, Fragogeorgi E, Psimadas D, Palamaris L, Loudos G. Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:38-38. https://hdl.handle.net/21.15107/rcub_dais_584 .
Stevanović, Magdalena, Nunić, Jana, Choi, Jonghoon, Filipović, Miloš, Uskoković, Dragan, Tsotakos, Theodore, Fragogeorgi, Eirini, Psimadas, Dimitris, Palamaris, Lazaros, Loudos, George, "Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):38-38, https://hdl.handle.net/21.15107/rcub_dais_584 .