Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model
Authors
Janićijević, Jelena M.Najman, Stevo
Ignjatović, Nenad
Savić, Vojin P.
Kocić, Jelena S.
Vasiljević, Perica
Vukelić, Marija Đ.
Uskoković, Dragan
Article (Published version)
Metadata
Show full item recordAbstract
The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.
Source:
Hemijska industrija, 2008, 62, 3, 205-210Publisher:
- Belgrade : Association of the Chemical Engineers of Serbia
Funding / projects:
- Regeneracija skeletnih tkiva pomognuta biomaterijalima kao tkivnim matricama - in vivo i in vitro studija (RS-MESTD-MPN2006-2010-145072)
DOI: 10.2298/HEMIND0803205J
ISSN: 0367-598X
WoS: 000257697700019
Scopus: 2-s2.0-77952907590
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Janićijević, Jelena M. AU - Najman, Stevo AU - Ignjatović, Nenad AU - Savić, Vojin P. AU - Kocić, Jelena S. AU - Vasiljević, Perica AU - Vukelić, Marija Đ. AU - Uskoković, Dragan PY - 2008 UR - http://www.ncbi.nlm.nih.gov/pubmed/0367-598X0803205J UR - https://dais.sanu.ac.rs/123456789/3363 AB - The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation. PB - Belgrade : Association of the Chemical Engineers of Serbia T2 - Hemijska industrija T2 - Hemijska industrija T1 - Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model SP - 205 EP - 210 VL - 62 IS - 3 DO - 10.2298/HEMIND0803205J UR - https://hdl.handle.net/21.15107/rcub_dais_3363 ER -
@article{ author = "Janićijević, Jelena M. and Najman, Stevo and Ignjatović, Nenad and Savić, Vojin P. and Kocić, Jelena S. and Vasiljević, Perica and Vukelić, Marija Đ. and Uskoković, Dragan", year = "2008", abstract = "The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.", publisher = "Belgrade : Association of the Chemical Engineers of Serbia", journal = "Hemijska industrija, Hemijska industrija", title = "Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model", pages = "205-210", volume = "62", number = "3", doi = "10.2298/HEMIND0803205J", url = "https://hdl.handle.net/21.15107/rcub_dais_3363" }
Janićijević, J. M., Najman, S., Ignjatović, N., Savić, V. P., Kocić, J. S., Vasiljević, P., Vukelić, M. Đ.,& Uskoković, D.. (2008). Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model. in Hemijska industrija Belgrade : Association of the Chemical Engineers of Serbia., 62(3), 205-210. https://doi.org/10.2298/HEMIND0803205J https://hdl.handle.net/21.15107/rcub_dais_3363
Janićijević JM, Najman S, Ignjatović N, Savić VP, Kocić JS, Vasiljević P, Vukelić MĐ, Uskoković D. Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model. in Hemijska industrija. 2008;62(3):205-210. doi:10.2298/HEMIND0803205J https://hdl.handle.net/21.15107/rcub_dais_3363 .
Janićijević, Jelena M., Najman, Stevo, Ignjatović, Nenad, Savić, Vojin P., Kocić, Jelena S., Vasiljević, Perica, Vukelić, Marija Đ., Uskoković, Dragan, "Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model" in Hemijska industrija, 62, no. 3 (2008):205-210, https://doi.org/10.2298/HEMIND0803205J ., https://hdl.handle.net/21.15107/rcub_dais_3363 .