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Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue

Authorized Users Only
2005
Authors
Ignjatović, Nenad
Ninkov, Petar
Ajduković, Zorica
Konstantinović, Vitomir
Uskoković, Dragan
Article (Published version)
Metadata
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Abstract
Composite biomaterials, like calciumphosphate/bioresorbable polymer, offer excellent potential for reconstruction and reparation of bone tissue defects induced by different sources. In this paper synthesis of calciumphosphate/poly-DL-lactide-co-glycolide (BCP/DLPLG) composite biomaterial formed as filler and blocks was studied. BCP/DLPLG composite biomaterial was produced in the form of spherical granules of BCP covered by a DLPLG layer, average diameter of 150-250 mu m. By cold and hot pressing of granules at up to 10000 kg/cm(2), blocks with fine distribution of phases and porosity up to 3% were obtained. Characterization was performed by wide-angle X-ray structural analysis (WAXS), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), infrared spectroscopy (IR), and mechanical properties by defining the compressive strength. In vitro citotoxicity research was carried out on cellular cultures of fibroblasts of human (MRC5) and mouse (L929). In vivo research was... performed in two steps. Reparatory ability of BCP/DLPLG in mice was examined in the first step, and then bone tissue reconstruction possibilities on 10 patients in the next step. In vitro tests showed very good fibroblast adhesion and non-citotoxicity of the composite. A material is considered non-cytotoxic if the cell survival is above 50%, and in our case it was 90%. In vivo research on mice indicated high level of reparatory ability of this composite with formation of new bone and vascular tissue six weeks after reparation. Application of this composite for healing infrabone defects of patients showed a high level of osseous regeneration.

Keywords:
bone repair / calcium phosphate / composite / cytotoxicity / in vitro / in vivo
Source:
Current Research in Advanced Materials & Processes, 2005, 519-524
Publisher:
  • Durnten-Zurich : Trans Tech Publications Ltd.
Note:
  • Materials Science Forum, Vol. 494

DOI: 10.4028/www.scientific.net/MSF.494.519

ISSN: 0255-5476

WoS: 000230985800085

[ Google Scholar ]
18
URI
http://dais.sanu.ac.rs/123456789/8952
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Ninkov, Petar
AU  - Ajduković, Zorica
AU  - Konstantinović, Vitomir
AU  - Uskoković, Dragan
PY  - 2005
UR  - http://dais.sanu.ac.rs/123456789/8952
AB  - Composite biomaterials, like calciumphosphate/bioresorbable polymer, offer excellent potential for reconstruction and reparation of bone tissue defects induced by different sources. In this paper synthesis of calciumphosphate/poly-DL-lactide-co-glycolide (BCP/DLPLG) composite biomaterial formed as filler and blocks was studied. BCP/DLPLG composite biomaterial was produced in the form of spherical granules of BCP covered by a DLPLG layer, average diameter of 150-250 mu m. By cold and hot pressing of granules at up to 10000 kg/cm(2), blocks with fine distribution of phases and porosity up to 3% were obtained. Characterization was performed by wide-angle X-ray structural analysis (WAXS), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), infrared spectroscopy (IR), and mechanical properties by defining the compressive strength. In vitro citotoxicity research was carried out on cellular cultures of fibroblasts of human (MRC5) and mouse (L929). In vivo research was performed in two steps. Reparatory ability of BCP/DLPLG in mice was examined in the first step, and then bone tissue reconstruction possibilities on 10 patients in the next step. In vitro tests showed very good fibroblast adhesion and non-citotoxicity of the composite. A material is considered non-cytotoxic if the cell survival is above 50%, and in our case it was 90%. In vivo research on mice indicated high level of reparatory ability of this composite with formation of new bone and vascular tissue six weeks after reparation. Application of this composite for healing infrabone defects of patients showed a high level of osseous regeneration.
PB  - Durnten-Zurich : Trans Tech Publications Ltd.
T2  - Current Research in Advanced Materials & Processes
T1  - Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue
SP  - 519
EP  - 524
DO  - 10.4028/www.scientific.net/MSF.494.519
ER  - 
@article{
author = "Ignjatović, Nenad and Ninkov, Petar and Ajduković, Zorica and Konstantinović, Vitomir and Uskoković, Dragan",
year = "2005",
url = "http://dais.sanu.ac.rs/123456789/8952",
abstract = "Composite biomaterials, like calciumphosphate/bioresorbable polymer, offer excellent potential for reconstruction and reparation of bone tissue defects induced by different sources. In this paper synthesis of calciumphosphate/poly-DL-lactide-co-glycolide (BCP/DLPLG) composite biomaterial formed as filler and blocks was studied. BCP/DLPLG composite biomaterial was produced in the form of spherical granules of BCP covered by a DLPLG layer, average diameter of 150-250 mu m. By cold and hot pressing of granules at up to 10000 kg/cm(2), blocks with fine distribution of phases and porosity up to 3% were obtained. Characterization was performed by wide-angle X-ray structural analysis (WAXS), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), infrared spectroscopy (IR), and mechanical properties by defining the compressive strength. In vitro citotoxicity research was carried out on cellular cultures of fibroblasts of human (MRC5) and mouse (L929). In vivo research was performed in two steps. Reparatory ability of BCP/DLPLG in mice was examined in the first step, and then bone tissue reconstruction possibilities on 10 patients in the next step. In vitro tests showed very good fibroblast adhesion and non-citotoxicity of the composite. A material is considered non-cytotoxic if the cell survival is above 50%, and in our case it was 90%. In vivo research on mice indicated high level of reparatory ability of this composite with formation of new bone and vascular tissue six weeks after reparation. Application of this composite for healing infrabone defects of patients showed a high level of osseous regeneration.",
publisher = "Durnten-Zurich : Trans Tech Publications Ltd.",
journal = "Current Research in Advanced Materials & Processes",
title = "Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue",
pages = "519-524",
doi = "10.4028/www.scientific.net/MSF.494.519"
}
Ignjatović N, Ninkov P, Ajduković Z, Konstantinović V, Uskoković D. Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue. Current Research in Advanced Materials & Processes. 2005;:519-524
Ignjatović, N., Ninkov, P., Ajduković, Z., Konstantinović, V.,& Uskoković, D. (2005). Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue.
Current Research in Advanced Materials & ProcessesDurnten-Zurich : Trans Tech Publications Ltd.., null, 519-524. 
https://doi.org/10.4028/www.scientific.net/MSF.494.519
Ignjatović Nenad, Ninkov Petar, Ajduković Zorica, Konstantinović Vitomir, Uskoković Dragan, "Biphasic calcium phosphate/poly-(DL-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue" null (2005):519-524,
https://doi.org/10.4028/www.scientific.net/MSF.494.519 .

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