DAIS - Digital Archive of the Serbian Academy of Sciences and Arts
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
  • View Item
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles

Thumbnail
2015
853.pdf (334.2Kb)
Authors
Boccaccini, Aldo
Stevanović, Magdalena
Filipović, Nenad
Veselinović, Ljiljana
Lukić, Miodrag J.
Milenković, Marina
Conference object (Published version)
Metadata
Show full item record
Abstract
In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Un...iform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections.

Keywords:
45S5 bioglass / scaffolds / poly(lactide-co-glycolide) / selenium / nanoparticles
Source:
European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015, 2015
Publisher:
  • Weimar : Deutsche Gesellschaft für Materialkunde e.V.
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/856
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Boccaccini, Aldo
AU  - Stevanović, Magdalena
AU  - Filipović, Nenad
AU  - Veselinović, Ljiljana
AU  - Lukić, Miodrag J.
AU  - Milenković, Marina
PY  - 2015
UR  - http://dais.sanu.ac.rs/123456789/856
AB  - In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Uniform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections.
PB  - Weimar : Deutsche Gesellschaft für Materialkunde e.V.
C3  - European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015
T1  - Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles
ER  - 
@conference{
author = "Boccaccini, Aldo and Stevanović, Magdalena and Filipović, Nenad and Veselinović, Ljiljana and Lukić, Miodrag J. and Milenković, Marina",
year = "2015",
url = "http://dais.sanu.ac.rs/123456789/856",
abstract = "In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Uniform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections.",
publisher = "Weimar : Deutsche Gesellschaft für Materialkunde e.V.",
journal = "European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015",
title = "Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles"
}
Boccaccini A, Stevanović M, Filipović N, Veselinović L, Lukić MJ, Milenković M. Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles. European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015. 2015;
Boccaccini, A., Stevanović, M., Filipović, N., Veselinović, L., Lukić, M. J.,& Milenković, M. (2015). Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles.
European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015Weimar : Deutsche Gesellschaft für Materialkunde e.V.., null. 
Boccaccini Aldo, Stevanović Magdalena, Filipović Nenad, Veselinović Ljiljana, Lukić Miodrag J., Milenković Marina, "Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles" null (2015)

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB