Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles

2015
Authors
Boccaccini, Aldo
Stevanović, Magdalena

Filipović, Nenad

Veselinović, Ljiljana

Lukić, Miodrag J.

Milenković, Marina

Conference object (Published version)
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In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Un...iform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections.
Keywords:
45S5 bioglass / scaffolds / poly(lactide-co-glycolide) / selenium / nanoparticlesSource:
European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015, 2015Publisher:
- Weimar : Deutsche Gesellschaft für Materialkunde e.V.
Funding / projects:
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Boccaccini, Aldo AU - Stevanović, Magdalena AU - Filipović, Nenad AU - Veselinović, Ljiljana AU - Lukić, Miodrag J. AU - Milenković, Marina PY - 2015 UR - https://dais.sanu.ac.rs/123456789/856 AB - In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Uniform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. PB - Weimar : Deutsche Gesellschaft für Materialkunde e.V. C3 - European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015 T1 - Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles UR - https://hdl.handle.net/21.15107/rcub_dais_856 ER -
@conference{ author = "Boccaccini, Aldo and Stevanović, Magdalena and Filipović, Nenad and Veselinović, Ljiljana and Lukić, Miodrag J. and Milenković, Marina", year = "2015", abstract = "In the bone tissue engineering field, there is growing interest in the application of bioglass scaffolds due to their bone bonding ability and osteoconductivity. However such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. enhanced bioactivity by incorporation of bioactive molecules or growth factors and effective antibacterial properties. A large number of epidemiological, preclinical, and clinical trials suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. Studies also provide evidence that Se intake may be necessary for bone health. Poly(lactide-co-glycolide) (PLGA) micro and nanoparticles are used for the controlled delivery of several classes of medicaments such as growth factors, antibiotics, antimicrobial agents etc. Uniform, stable, amorphous SeNps have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). Bioglass scaffolds have been synthesized by foam replica method and additionally coated by SeNp or by PLGA with encapsulated SeNp. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, Bioglass®/SeNp and Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections.", publisher = "Weimar : Deutsche Gesellschaft für Materialkunde e.V.", journal = "European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015", title = "Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles", url = "https://hdl.handle.net/21.15107/rcub_dais_856" }
Boccaccini, A., Stevanović, M., Filipović, N., Veselinović, L., Lukić, M. J.,& Milenković, M.. (2015). Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles. in European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015 Weimar : Deutsche Gesellschaft für Materialkunde e.V... https://hdl.handle.net/21.15107/rcub_dais_856
Boccaccini A, Stevanović M, Filipović N, Veselinović L, Lukić MJ, Milenković M. Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles. in European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015. 2015;. https://hdl.handle.net/21.15107/rcub_dais_856 .
Boccaccini, Aldo, Stevanović, Magdalena, Filipović, Nenad, Veselinović, Ljiljana, Lukić, Miodrag J., Milenković, Marina, "Development and evaluation of 45S5 bioglass scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium nanoparticles" in European Symposium and Exhibition on Biomaterials and Related Areas (Euro BioMAT), Weimar, Germany, 2015 (2015), https://hdl.handle.net/21.15107/rcub_dais_856 .