Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins
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Controlled drug delivery systems and polymeric carriers have undergone significant development in recent years. Polymers like polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy. Owing to their biodegradable nature, polymer materials, such as copolymer poly(DL-lactide-co-glycolide), are widely used in various medical applications; controlled release of delivering drugs, carriers in the tissue engineering, fixation of bone fractures, chirurgical strings, etc. Polymeric particles are used for the controlled delivery of several types of medicaments, including anticancer agents, antihypertensive agents, immunomodulatory drugs, hormones, vitamins and macromolecules, such as nucleic acid, proteins, peptides, antibodies, etc. Preparation of poly(lactide-co-glycolide) submicron spheres poses serious challenges. The present r...eview attempts to address some important issues related to micro/nanoparticle-based delivery systems comprising poly(lactide-co-glycolide), with a special reference to PLGA for the controlled delivery of vitamins. A range of topics is discussed, including formulation aspects of micro- and nanoparticles, the effects of particle size and size distribution, most commonly used incorporation techniques, surface modification with stabilizers, surface functionalization, and factors affecting degradation and drug release rate.
Keywords:
poly(lactide-co-glycolide) / microparticles / nanoparticles / drug delivery / drug release / vitaminsSource:
Current Nanoscience, 2009, 5, 1, 1-14Publisher:
- Bentham Science
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
Note:
- This is the peer reviewed version of the article: Uskokovic, Dragan, and Magdalena Stevanovic. 2009. “Poly(lactide-Co-Glycolide)-Based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins.” Current Nanoscience 5 (1) (February 1): 1–14. http://dx.doi.org/10.3109/17435390.2010.507316
DOI: 10.2174/157341309787314566
ISSN: 1573-4137
WoS: 000263961400001
Scopus: 2-s2.0-65949099508
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Uskoković, Dragan PY - 2009 UR - https://dais.sanu.ac.rs/123456789/76 AB - Controlled drug delivery systems and polymeric carriers have undergone significant development in recent years. Polymers like polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy. Owing to their biodegradable nature, polymer materials, such as copolymer poly(DL-lactide-co-glycolide), are widely used in various medical applications; controlled release of delivering drugs, carriers in the tissue engineering, fixation of bone fractures, chirurgical strings, etc. Polymeric particles are used for the controlled delivery of several types of medicaments, including anticancer agents, antihypertensive agents, immunomodulatory drugs, hormones, vitamins and macromolecules, such as nucleic acid, proteins, peptides, antibodies, etc. Preparation of poly(lactide-co-glycolide) submicron spheres poses serious challenges. The present review attempts to address some important issues related to micro/nanoparticle-based delivery systems comprising poly(lactide-co-glycolide), with a special reference to PLGA for the controlled delivery of vitamins. A range of topics is discussed, including formulation aspects of micro- and nanoparticles, the effects of particle size and size distribution, most commonly used incorporation techniques, surface modification with stabilizers, surface functionalization, and factors affecting degradation and drug release rate. PB - Bentham Science T2 - Current Nanoscience T1 - Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins SP - 1 EP - 14 VL - 5 IS - 1 DO - 10.2174/157341309787314566 UR - https://hdl.handle.net/21.15107/rcub_dais_76 ER -
@article{ author = "Stevanović, Magdalena and Uskoković, Dragan", year = "2009", abstract = "Controlled drug delivery systems and polymeric carriers have undergone significant development in recent years. Polymers like polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy. Owing to their biodegradable nature, polymer materials, such as copolymer poly(DL-lactide-co-glycolide), are widely used in various medical applications; controlled release of delivering drugs, carriers in the tissue engineering, fixation of bone fractures, chirurgical strings, etc. Polymeric particles are used for the controlled delivery of several types of medicaments, including anticancer agents, antihypertensive agents, immunomodulatory drugs, hormones, vitamins and macromolecules, such as nucleic acid, proteins, peptides, antibodies, etc. Preparation of poly(lactide-co-glycolide) submicron spheres poses serious challenges. The present review attempts to address some important issues related to micro/nanoparticle-based delivery systems comprising poly(lactide-co-glycolide), with a special reference to PLGA for the controlled delivery of vitamins. A range of topics is discussed, including formulation aspects of micro- and nanoparticles, the effects of particle size and size distribution, most commonly used incorporation techniques, surface modification with stabilizers, surface functionalization, and factors affecting degradation and drug release rate.", publisher = "Bentham Science", journal = "Current Nanoscience", title = "Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins", pages = "1-14", volume = "5", number = "1", doi = "10.2174/157341309787314566", url = "https://hdl.handle.net/21.15107/rcub_dais_76" }
Stevanović, M.,& Uskoković, D.. (2009). Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins. in Current Nanoscience Bentham Science., 5(1), 1-14. https://doi.org/10.2174/157341309787314566 https://hdl.handle.net/21.15107/rcub_dais_76
Stevanović M, Uskoković D. Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins. in Current Nanoscience. 2009;5(1):1-14. doi:10.2174/157341309787314566 https://hdl.handle.net/21.15107/rcub_dais_76 .
Stevanović, Magdalena, Uskoković, Dragan, "Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins" in Current Nanoscience, 5, no. 1 (2009):1-14, https://doi.org/10.2174/157341309787314566 ., https://hdl.handle.net/21.15107/rcub_dais_76 .