Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid
Authors
Vukelić, Marija Đ.
Mitić, Žarko
Miljković, Miroslav
Živković, Jelena M.
Ignjatović, Nenad

Uskoković, Dragan

Article (Published version)
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The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersiv...e X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.
Keywords:
biomaterials / hydroxyapatite / poly-l-lactide / simulated body fluidSource:
Acta medica Medianae, 2011, 50, 4, 35-39Publisher:
- Niš : University of Niš, Faculty of Medicine; Department of the Serbian Medical Society Niš
Funding / projects:
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Vukelić, Marija Đ. AU - Mitić, Žarko AU - Miljković, Miroslav AU - Živković, Jelena M. AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2011 UR - https://dais.sanu.ac.rs/123456789/701 AB - The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery. PB - Niš : University of Niš, Faculty of Medicine; Department of the Serbian Medical Society Niš T2 - Acta medica Medianae T1 - Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid SP - 35 EP - 39 VL - 50 IS - 4 DO - 10.5633/amm.2011.0406 UR - https://hdl.handle.net/21.15107/rcub_dais_701 ER -
@article{ author = "Vukelić, Marija Đ. and Mitić, Žarko and Miljković, Miroslav and Živković, Jelena M. and Ignjatović, Nenad and Uskoković, Dragan", year = "2011", abstract = "The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.", publisher = "Niš : University of Niš, Faculty of Medicine; Department of the Serbian Medical Society Niš", journal = "Acta medica Medianae", title = "Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid", pages = "35-39", volume = "50", number = "4", doi = "10.5633/amm.2011.0406", url = "https://hdl.handle.net/21.15107/rcub_dais_701" }
Vukelić, M. Đ., Mitić, Ž., Miljković, M., Živković, J. M., Ignjatović, N.,& Uskoković, D.. (2011). Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid. in Acta medica Medianae Niš : University of Niš, Faculty of Medicine; Department of the Serbian Medical Society Niš., 50(4), 35-39. https://doi.org/10.5633/amm.2011.0406 https://hdl.handle.net/21.15107/rcub_dais_701
Vukelić MĐ, Mitić Ž, Miljković M, Živković JM, Ignjatović N, Uskoković D. Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid. in Acta medica Medianae. 2011;50(4):35-39. doi:10.5633/amm.2011.0406 https://hdl.handle.net/21.15107/rcub_dais_701 .
Vukelić, Marija Đ., Mitić, Žarko, Miljković, Miroslav, Živković, Jelena M., Ignjatović, Nenad, Uskoković, Dragan, "Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid" in Acta medica Medianae, 50, no. 4 (2011):35-39, https://doi.org/10.5633/amm.2011.0406 ., https://hdl.handle.net/21.15107/rcub_dais_701 .