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Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid

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2011
bitstream_6935.pdf (1.593Mb)
Authors
Vukelić, Marija Đ.
Mitić, Žarko
Miljković, Miroslav
Živković, Jelena M.
Ignjatović, Nenad
Uskoković, Dragan
Article (Published version)
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Abstract
The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersiv...e X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.

Keywords:
biomaterials / hydroxyapatite / poly-l-lactide / simulated body fluid
Source:
Acta medica Medianae, 2011, 50, 4, 35-39
Publisher:
  • Niš : University of Niš, Faculty of Medicine; Department of the Serbian Medical Society Niš
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)

DOI: 10.5633/amm.2011.0406

ISSN: 0365-4478 (Print); 1821-2794 (Online)

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_701
URI
https://dais.sanu.ac.rs/123456789/701
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Vukelić, Marija Đ.
AU  - Mitić, Žarko
AU  - Miljković, Miroslav
AU  - Živković, Jelena M.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/701
AB  - The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.
PB  - Niš : University of Niš, Faculty of Medicine; Department of  the Serbian Medical Society Niš
T2  - Acta medica Medianae
T1  - Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid
SP  - 35
EP  - 39
VL  - 50
IS  - 4
DO  - 10.5633/amm.2011.0406
UR  - https://hdl.handle.net/21.15107/rcub_dais_701
ER  - 
@article{
author = "Vukelić, Marija Đ. and Mitić, Žarko and Miljković, Miroslav and Živković, Jelena M. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2011",
abstract = "The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.",
publisher = "Niš : University of Niš, Faculty of Medicine; Department of  the Serbian Medical Society Niš",
journal = "Acta medica Medianae",
title = "Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid",
pages = "35-39",
volume = "50",
number = "4",
doi = "10.5633/amm.2011.0406",
url = "https://hdl.handle.net/21.15107/rcub_dais_701"
}
Vukelić, M. Đ., Mitić, Ž., Miljković, M., Živković, J. M., Ignjatović, N.,& Uskoković, D.. (2011). Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid. in Acta medica Medianae
Niš : University of Niš, Faculty of Medicine; Department of  the Serbian Medical Society Niš., 50(4), 35-39.
https://doi.org/10.5633/amm.2011.0406
https://hdl.handle.net/21.15107/rcub_dais_701
Vukelić MĐ, Mitić Ž, Miljković M, Živković JM, Ignjatović N, Uskoković D. Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid. in Acta medica Medianae. 2011;50(4):35-39.
doi:10.5633/amm.2011.0406
https://hdl.handle.net/21.15107/rcub_dais_701 .
Vukelić, Marija Đ., Mitić, Žarko, Miljković, Miroslav, Živković, Jelena M., Ignjatović, Nenad, Uskoković, Dragan, "Interaction of biomaterial containing calcium hydroxyapatite/poly-l-lactide with simulated body fluid" in Acta medica Medianae, 50, no. 4 (2011):35-39,
https://doi.org/10.5633/amm.2011.0406 .,
https://hdl.handle.net/21.15107/rcub_dais_701 .

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