Show simple item record

dc.creatorRakić, Mia
dc.creatorIgnjatović, Nenad
dc.creatorSanz, Mariano
dc.date.accessioned2020-01-07T18:39:37Z
dc.date.available2020-01-07T18:39:37Z
dc.date.issued2019
dc.identifier.urihttps://www.ced-iadr2019.com/Madrid_Abstract_BOOK_Sept_7.pdf
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/6984
dc.description.abstractObjectives To compare biological effects of experimental nano device composed of nano-hydroxyapatite loaded with clindamycin, embedded in PLGA for continual release of daily MIC against Porphiromonas gingivalis for 21 days bone healing period (CLHap) with effects of nano-hydroxyapatite (Hap) and commercial bone substituent (BioOssÒ). Methods 6 female beagle dogs with similar characteristics underwent teeth extractions, implant placement and ligature induced PI, and were further surgically treated. Following open-flap debridement, the biomaterials were randomly allocated to ensure the serial distribution of antimicrobial material for pharmacokinetic testing of antibiotic systemic release. The biochemical and microbiological markers were compared before disease induction (baseline), before the treatment (pre-op) and 3 months (3m) following treatment. GM-CSF, TNFa, IL-6, IL-10 and OPG concentrations were estimated using Luminex method, while the RT-PCR kit was developed for quantification of the Porphyromonas gulae. Finally, following animal sacrifice, specimens were retrieved for histological analyses. Following fracture technique, decalcified samples were sectioned and stained for histomorphometric assessment of: apical extension of barrier epithelium (aBE), infiltrated connective tissue (ICT) area and respective apical extension (aICT). Results The pharmacokinetic test confirmed safety of the experimental material according to undetectable blood concentrations of the antibiotic. The concentrations of P. Gulae, GM-CSF, TNFa, OPG, IL-6 and IL-10 significantly decreased following treatment only in CLHap group while in other groups the changes remained insignificant. Both ICT and aICT were significantly lower CLHap when compared to both control groups. Conclusions Results of the present study demonstrated safe and promising treatment capacity of the experimental CLHap for managment of peri-implantitis.en
dc.language.isoensr
dc.publisherMadrid : [s.n.]sr
dc.rightsopenAccesssr
dc.sourceAbstract Book / CED-IADR/NOF Oral Health Research Congress, 19-21 September 2019sr
dc.subjectperi-implantitissr
dc.subjectnanodevicessr
dc.subjectPLGAsr
dc.titleOne-shot Nano-device for Treatment of Peri-implantitis: Biological Proof of Concepten
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractРакић, Миа; Игњатовић, Ненад; Санз, Мариано; Оне-схот Нано-девице фор Треатмент оф Пери-имплантитис: Биологицал Прооф оф Цонцепт; Оне-схот Нано-девице фор Треатмент оф Пери-имплантитис: Биологицал Прооф оф Цонцепт;
dc.citation.spage77
dc.citation.epage78
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/27703/Rakic_CED-IADR-NOF.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record