Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines
Abstract
The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract.
Keywords:
calcium phosphate / poly- (DL-lactide-co-glycolide) / PLGA / cell lines / biomaterialsSource:
Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia, 2011, 6-6Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Projects:
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
- Virtual human osteoarticular system and its application in preclinical and clinical practice (RS-41017)