DAIS - Digital Archive of the Serbian Academy of Sciences and Arts
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles

Thumbnail
2019
Janicijevic_18YRC.pdf (3.185Mb)
Authors
Janićijević, Željko
Stanković, Ana
Žegura, Bojana
Veljović, Đorđe
Filipič, Metka
Stevanović, Magdalena
Conference object (Published version)
Metadata
Show full item record
Abstract
Nanostructured zinc oxides are promising materials for numerous biomedical applications where they can serve as therapeutic agents or tools for sensing and imaging. Despite their favorable properties, wider use of zinc oxide nanoparticles in biomedicine is limited by toxicity issues. Therefore, new synthesis approaches should be devised to obtain zinc oxide nanoparticles which are safe-by-design. We present an innovative low-cost wet precipitation synthesis of gelatin modified zinc oxide nanoparticles at the gel/liquid interface. The diffusion of ammonia through the gelatin hydrogels of different porosities induces precipitation of the product in contact with the surface of the aqueous solution of zinc ions. After thermal treatment of the precipitate, adsorbed organic residues of decomposed gelatin act as modifiers of zinc oxide nanoparticles. We characterized the physicochemical properties of obtained gelatin modified zinc oxide nanoparticles by XRD, FTIR, DTA/TG, and SEM. The synthes...ized nanoparticles show hexagonal wurtzite structure and form flakelike aggregates. FTIR and DTA/TG analyses indicate that the thermal decomposition of adsorbed gelatin depends on the gelatin content of the hydrogel used in the synthesis. We also examined the viability of HepG2 cells, generation of intracellular reactive oxygen species, and genotoxicity using the MTS, DCFH-DA, and alkaline comet assay, respectively. Fabricated gelatin modified zinc oxide nanoparticles show very low toxicity potential at doses relevant for human exposure.

Keywords:
zinc oxide / nanoparticles / gelatin / genotoxicity
Source:
Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia, 2019, 3-3
Publisher:
  • Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)

ISBN: 978-86-80321-35-6

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_6968
URI
https://dais.sanu.ac.rs/123456789/6968
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Janićijević, Željko
AU  - Stanković, Ana
AU  - Žegura, Bojana
AU  - Veljović, Đorđe
AU  - Filipič, Metka
AU  - Stevanović, Magdalena
PY  - 2019
UR  - https://dais.sanu.ac.rs/123456789/6968
AB  - Nanostructured zinc oxides are promising materials for numerous biomedical applications where they can serve as therapeutic agents or tools for sensing and imaging. Despite their favorable properties, wider use of zinc oxide nanoparticles in biomedicine is limited by toxicity issues. Therefore, new synthesis approaches should be devised to obtain zinc oxide nanoparticles which are safe-by-design. We present an innovative low-cost wet precipitation synthesis of gelatin modified zinc oxide nanoparticles at the gel/liquid interface. The diffusion of ammonia through the gelatin hydrogels of different porosities induces precipitation of the product in contact with the surface of the aqueous solution of zinc ions. After thermal treatment of the precipitate, adsorbed organic residues of decomposed gelatin act as modifiers of zinc oxide nanoparticles. We characterized the physicochemical properties of obtained gelatin modified zinc oxide nanoparticles by XRD, FTIR, DTA/TG, and SEM. The synthesized nanoparticles show hexagonal wurtzite structure and form flakelike aggregates. FTIR and DTA/TG analyses indicate that the thermal decomposition of adsorbed gelatin depends on the gelatin content of the hydrogel used in the synthesis. We also examined the viability of HepG2 cells, generation of intracellular reactive oxygen species, and genotoxicity using the MTS, DCFH-DA, and alkaline comet assay, respectively. Fabricated gelatin modified zinc oxide nanoparticles show very low toxicity potential at doses relevant for human exposure.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia
T1  - Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles
SP  - 3
EP  - 3
UR  - https://hdl.handle.net/21.15107/rcub_dais_6968
ER  - 
@conference{
author = "Janićijević, Željko and Stanković, Ana and Žegura, Bojana and Veljović, Đorđe and Filipič, Metka and Stevanović, Magdalena",
year = "2019",
abstract = "Nanostructured zinc oxides are promising materials for numerous biomedical applications where they can serve as therapeutic agents or tools for sensing and imaging. Despite their favorable properties, wider use of zinc oxide nanoparticles in biomedicine is limited by toxicity issues. Therefore, new synthesis approaches should be devised to obtain zinc oxide nanoparticles which are safe-by-design. We present an innovative low-cost wet precipitation synthesis of gelatin modified zinc oxide nanoparticles at the gel/liquid interface. The diffusion of ammonia through the gelatin hydrogels of different porosities induces precipitation of the product in contact with the surface of the aqueous solution of zinc ions. After thermal treatment of the precipitate, adsorbed organic residues of decomposed gelatin act as modifiers of zinc oxide nanoparticles. We characterized the physicochemical properties of obtained gelatin modified zinc oxide nanoparticles by XRD, FTIR, DTA/TG, and SEM. The synthesized nanoparticles show hexagonal wurtzite structure and form flakelike aggregates. FTIR and DTA/TG analyses indicate that the thermal decomposition of adsorbed gelatin depends on the gelatin content of the hydrogel used in the synthesis. We also examined the viability of HepG2 cells, generation of intracellular reactive oxygen species, and genotoxicity using the MTS, DCFH-DA, and alkaline comet assay, respectively. Fabricated gelatin modified zinc oxide nanoparticles show very low toxicity potential at doses relevant for human exposure.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia",
title = "Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles",
pages = "3-3",
url = "https://hdl.handle.net/21.15107/rcub_dais_6968"
}
Janićijević, Ž., Stanković, A., Žegura, B., Veljović, Đ., Filipič, M.,& Stevanović, M.. (2019). Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles. in Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 3-3.
https://hdl.handle.net/21.15107/rcub_dais_6968
Janićijević Ž, Stanković A, Žegura B, Veljović Đ, Filipič M, Stevanović M. Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles. in Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia. 2019;:3-3.
https://hdl.handle.net/21.15107/rcub_dais_6968 .
Janićijević, Željko, Stanković, Ana, Žegura, Bojana, Veljović, Đorđe, Filipič, Metka, Stevanović, Magdalena, "Synthesis, characterization and toxicity studies of gelatin modified zinc oxide nanoparticles" in Program and the Book of abstracts / Eighteenth Young Researchers' Conference Materials Sciences and Engineering, December 4-6, 2019, Belgrade, Serbia (2019):3-3,
https://hdl.handle.net/21.15107/rcub_dais_6968 .

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB