On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature
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Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%.
Source:
Zaštita materijala, 2019, 60, 3, 229-236Publisher:
- Belgrade : Engineers Society of Corrosion
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
- Nanostructured Functional and Composite Materials in Catalytic and Sorption Processes (RS-45001)
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https://scindeks.ceon.rs/article.aspx?artid=0351-94651903229Zhttp://www.ncbi.nlm.nih.gov/pubmed/0351-94651903229Z
https://dais.sanu.ac.rs/123456789/6954
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Zdujić, Miodrag AU - Petrović, Slobodan D. AU - Valentić, Nataša V. AU - Mijin, Dušan PY - 2019 UR - https://scindeks.ceon.rs/article.aspx?artid=0351-94651903229Z UR - http://www.ncbi.nlm.nih.gov/pubmed/0351-94651903229Z UR - https://dais.sanu.ac.rs/123456789/6954 AB - Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%. PB - Belgrade : Engineers Society of Corrosion T2 - Zaštita materijala T1 - On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature SP - 229 EP - 236 VL - 60 IS - 3 DO - 10.5937/zasmat1903229Z UR - https://hdl.handle.net/21.15107/rcub_dais_6954 ER -
@article{ author = "Zdujić, Miodrag and Petrović, Slobodan D. and Valentić, Nataša V. and Mijin, Dušan", year = "2019", abstract = "Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%.", publisher = "Belgrade : Engineers Society of Corrosion", journal = "Zaštita materijala", title = "On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature", pages = "229-236", volume = "60", number = "3", doi = "10.5937/zasmat1903229Z", url = "https://hdl.handle.net/21.15107/rcub_dais_6954" }
Zdujić, M., Petrović, S. D., Valentić, N. V.,& Mijin, D.. (2019). On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature. in Zaštita materijala Belgrade : Engineers Society of Corrosion., 60(3), 229-236. https://doi.org/10.5937/zasmat1903229Z https://hdl.handle.net/21.15107/rcub_dais_6954
Zdujić M, Petrović SD, Valentić NV, Mijin D. On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature. in Zaštita materijala. 2019;60(3):229-236. doi:10.5937/zasmat1903229Z https://hdl.handle.net/21.15107/rcub_dais_6954 .
Zdujić, Miodrag, Petrović, Slobodan D., Valentić, Nataša V., Mijin, Dušan, "On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature" in Zaštita materijala, 60, no. 3 (2019):229-236, https://doi.org/10.5937/zasmat1903229Z ., https://hdl.handle.net/21.15107/rcub_dais_6954 .