Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%.
TY - JOUR
AU - Zdujić, Miodrag
AU - Petrović, Slobodan D.
AU - Valentić, Nataša V.
AU - Mijin, Dušan
PY - 2019
AB - Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%.
PB - Belgrade : Engineers Society of Corrosion
T2 - Zaštita materijala
T1 - On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature
SP - 229
EP - 236
VL - 60
IS - 3
DO - 10.5937/zasmat1903229Z
UR - https://hdl.handle.net/21.15107/rcub_dais_6954
ER -
@article{
author = "Zdujić, Miodrag and Petrović, Slobodan D. and Valentić, Nataša V. and Mijin, Dušan",
year = "2019",
abstract = "Milling of cyanoacetamide and acetoacetic ester as reactants, in the presence of KOH as the catalyst and ethanol as a viscous control agent (VCA) was performed in a planetary ball mill with the goal of investigating the effect of mechanochemical treatment for the synthesis of 3-cyano-6hydroxy-4-methyl-2-pyridone at room temperature. The mechanochemical synthesis was performed under various milling parameters, i.e. milling time up to 4 h, number and size of balls, angular velocity as well as molar ratio of reactants and the amount of catalyst. The obtained product was characterized by m.p., UV, IR and NMR data. It was fond that the dominant process parameter is the milling time while others are of less importance. The highest isolated yield after milling was up to 56%. The combination of milling and aging increase yield over 60%.",
publisher = "Belgrade : Engineers Society of Corrosion",
journal = "Zaštita materijala",
title = "On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature",
pages = "229-236",
volume = "60",
number = "3",
doi = "10.5937/zasmat1903229Z",
url = "https://hdl.handle.net/21.15107/rcub_dais_6954"
}
Zdujić, M., Petrović, S. D., Valentić, N. V.,& Mijin, D. (2019). On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature.
Zaštita materijala
Belgrade : Engineers Society of Corrosion., 60(3), 229-236.
https://doi.org/10.5937/zasmat1903229Z
Zdujić M, Petrović SD, Valentić NV, Mijin D. On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature. Zaštita materijala. 2019;60(3):229-236.
doi:10.5937/zasmat1903229Z.
Zdujić Miodrag, Petrović Slobodan D., Valentić Nataša V., Mijin Dušan, "On the synthesis of 3-cyano-6-hydroxy-4-methyl-2-pyridone at room temperature" Zaštita materijala, 60, no. 3 (2019):229-236,
https://doi.org/10.5937/zasmat1903229Z .
