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Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466

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Authors
Janićijević, Željko
Vujčić, Ivica
Veljović, Đorđe
Vujisić, Miloš
Radovanović, Filip
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Abstract
Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of... this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.

Keywords:
composite hydrogel / gamma irradiation / ion exchange / PLGA / polymerization / radiation-induced synthesis
Source:
Radiation Physics and Chemistry, 2020, 166
Funding / projects:
  • Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
Note:
  • Supplementary information for the article: https://doi.org/10.1016/j.radphyschem.2019.108466
Related info:
  • Referenced by
    https://doi.org/10.1016/j.radphyschem.2019.108466
  • Referenced by
    https://hdl.handle.net/21.15107/rcub_dais_6943
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_6944
URI
https://dais.sanu.ac.rs/123456789/6944
Collections
  • ИТН САНУ Истраживачки подаци / ITS SASA Research data
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - DATA
AU  - Janićijević, Željko
AU  - Vujčić, Ivica
AU  - Veljović, Đorđe
AU  - Vujisić, Miloš
AU  - Radovanović, Filip
PY  - 2020
UR  - https://dais.sanu.ac.rs/123456789/6944
AB  - Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.
T2  - Radiation Physics and Chemistry
T1  - Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466
VL  - 166
UR  - https://hdl.handle.net/21.15107/rcub_dais_6944
ER  - 
@misc{
author = "Janićijević, Željko and Vujčić, Ivica and Veljović, Đorđe and Vujisić, Miloš and Radovanović, Filip",
year = "2020",
abstract = "Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.",
journal = "Radiation Physics and Chemistry",
title = "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466",
volume = "166",
url = "https://hdl.handle.net/21.15107/rcub_dais_6944"
}
Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M.,& Radovanović, F.. (2020). Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466. in Radiation Physics and Chemistry, 166.
https://hdl.handle.net/21.15107/rcub_dais_6944
Janićijević Ž, Vujčić I, Veljović Đ, Vujisić M, Radovanović F. Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466. in Radiation Physics and Chemistry. 2020;166.
https://hdl.handle.net/21.15107/rcub_dais_6944 .
Janićijević, Željko, Vujčić, Ivica, Veljović, Đorđe, Vujisić, Miloš, Radovanović, Filip, "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466" in Radiation Physics and Chemistry, 166 (2020),
https://hdl.handle.net/21.15107/rcub_dais_6944 .

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