Poly-ε-caprolactone (PCL) is a semicrystalline, biodegradable and biocompatible polymer. Its advantages, as high permeability to small drug molecules, failure to generate an acidic environment during degradation (as compared to polylactides and polyglycolides) and a slow degradation rate, make this aliphatic polyester suitable for extended long-term delivery over a period of more than one year. In this study PCL particles were prepared by physicochemical method with solvent/nonsolvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly (α, γ, L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. Characterization of obtained particles was performed by Fourier transform infrared spectroscopy. The morphology and size distribution were determined using SEM and particle analyzer.
Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia, 2011, 2-2
Publisher:
Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
TY - CONF
AU - Filipović, Nenad
AU - Stevanović, Magdalena
AU - Pavlović, Vladimir B.
AU - Radulović, Aleksandra
AU - Stojanović, Zoran S.
AU - Uskoković, Dragan
PY - 2011
UR - https://dais.sanu.ac.rs/123456789/692
AB - Poly-ε-caprolactone (PCL) is a semicrystalline, biodegradable and biocompatible polymer. Its advantages, as high permeability to small drug molecules, failure to generate an acidic environment during degradation (as compared to polylactides and polyglycolides) and a slow degradation rate, make this aliphatic polyester suitable for extended long-term delivery over a period of more than one year. In this study PCL particles were prepared by physicochemical method with solvent/nonsolvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly (α, γ, L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. Characterization of obtained particles was performed by Fourier transform infrared spectroscopy. The morphology and size distribution were determined using SEM and particle analyzer.
PB - Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
C3 - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
T1 - Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres
SP - 2
EP - 2
UR - https://hdl.handle.net/21.15107/rcub_dais_692
ER -
@conference{
author = "Filipović, Nenad and Stevanović, Magdalena and Pavlović, Vladimir B. and Radulović, Aleksandra and Stojanović, Zoran S. and Uskoković, Dragan",
year = "2011",
abstract = "Poly-ε-caprolactone (PCL) is a semicrystalline, biodegradable and biocompatible polymer. Its advantages, as high permeability to small drug molecules, failure to generate an acidic environment during degradation (as compared to polylactides and polyglycolides) and a slow degradation rate, make this aliphatic polyester suitable for extended long-term delivery over a period of more than one year. In this study PCL particles were prepared by physicochemical method with solvent/nonsolvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly (α, γ, L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. Characterization of obtained particles was performed by Fourier transform infrared spectroscopy. The morphology and size distribution were determined using SEM and particle analyzer.",
publisher = "Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts",
journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia",
title = "Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_dais_692"
}
Filipović, N., Stevanović, M., Pavlović, V. B., Radulović, A., Stojanović, Z. S.,& Uskoković, D.. (2011). Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts., 2-2.
https://hdl.handle.net/21.15107/rcub_dais_692
Filipović N, Stevanović M, Pavlović VB, Radulović A, Stojanović ZS, Uskoković D. Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:2-2.
https://hdl.handle.net/21.15107/rcub_dais_692 .
Filipović, Nenad, Stevanović, Magdalena, Pavlović, Vladimir B., Radulović, Aleksandra, Stojanović, Zoran S., Uskoković, Dragan, "Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):2-2,
https://hdl.handle.net/21.15107/rcub_dais_692 .
