Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration

2011
Authors
Ajduković, Zorica
Ignjatović, Nenad

Petrović, Nenad
Savić, Vojin
Mihailović, Dragan
Uskoković, Dragan

Conference object (Published version)
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Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats’ mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, ...the animals were sacrificed, and the samples of mandibular alveolar bone were taken. The samples were adequately prepared and subjected to histopathological analysis. The best results in regeneration of osteoporotic jaw bone were obtained in the experimental group of animals where the implant was hydroxyapatite-coated vitamin D3 mixed with the polymer. The results show that nanobiomaterials with local delivery of active form of vitamin D3, used in this study, may be materials of the future in the area of weakened jaw bone tissue regeneration.
Keywords:
vitamin D / nanomaterials / biomaterials / bone regenerationSource:
Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia, 2011, 9-9Publisher:
- Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
Funding / projects:
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ajduković, Zorica AU - Ignjatović, Nenad AU - Petrović, Nenad AU - Savić, Vojin AU - Mihailović, Dragan AU - Uskoković, Dragan PY - 2011 UR - https://dais.sanu.ac.rs/123456789/690 AB - Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats’ mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, the animals were sacrificed, and the samples of mandibular alveolar bone were taken. The samples were adequately prepared and subjected to histopathological analysis. The best results in regeneration of osteoporotic jaw bone were obtained in the experimental group of animals where the implant was hydroxyapatite-coated vitamin D3 mixed with the polymer. The results show that nanobiomaterials with local delivery of active form of vitamin D3, used in this study, may be materials of the future in the area of weakened jaw bone tissue regeneration. PB - Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts C3 - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia T1 - Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration SP - 9 EP - 9 UR - https://hdl.handle.net/21.15107/rcub_dais_690 ER -
@conference{ author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Nenad and Savić, Vojin and Mihailović, Dragan and Uskoković, Dragan", year = "2011", abstract = "Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats’ mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, the animals were sacrificed, and the samples of mandibular alveolar bone were taken. The samples were adequately prepared and subjected to histopathological analysis. The best results in regeneration of osteoporotic jaw bone were obtained in the experimental group of animals where the implant was hydroxyapatite-coated vitamin D3 mixed with the polymer. The results show that nanobiomaterials with local delivery of active form of vitamin D3, used in this study, may be materials of the future in the area of weakened jaw bone tissue regeneration.", publisher = "Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts", journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia", title = "Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration", pages = "9-9", url = "https://hdl.handle.net/21.15107/rcub_dais_690" }
Ajduković, Z., Ignjatović, N., Petrović, N., Savić, V., Mihailović, D.,& Uskoković, D.. (2011). Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts., 9-9. https://hdl.handle.net/21.15107/rcub_dais_690
Ajduković Z, Ignjatović N, Petrović N, Savić V, Mihailović D, Uskoković D. Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:9-9. https://hdl.handle.net/21.15107/rcub_dais_690 .
Ajduković, Zorica, Ignjatović, Nenad, Petrović, Nenad, Savić, Vojin, Mihailović, Dragan, Uskoković, Dragan, "Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):9-9, https://hdl.handle.net/21.15107/rcub_dais_690 .