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Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3

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2011
676.pdf (90.36Kb)
Authors
Ignjatović, Nenad
Ajduković, Zorica
Drmanić, Saša Ž.
Uskoković, Dragan
Conference object (Published version)
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Abstract
Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were perfo...rmed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.

Keywords:
hydroxyapatite / vitamin D / controlled delivery / nanoparticles / osteogenesis
Source:
The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts, 2011, 68-68
Publisher:
  • Belgrade : Materials Research Society of Serbia
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/679
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Ignjatović, Nenad
AU  - Ajduković, Zorica
AU  - Drmanić, Saša Ž.
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://dais.sanu.ac.rs/123456789/679
AB  - Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
T1  - Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3
SP  - 68
EP  - 68
ER  - 
@conference{
author = "Ignjatović, Nenad and Ajduković, Zorica and Drmanić, Saša Ž. and Uskoković, Dragan",
year = "2011",
url = "http://dais.sanu.ac.rs/123456789/679",
abstract = "Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts",
title = "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3",
pages = "68-68"
}
Ignjatović N, Ajduković Z, Drmanić SŽ, Uskoković D. Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3. The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:68-68
Ignjatović, N., Ajduković, Z., Drmanić, S. Ž.,& Uskoković, D. (2011). Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3.
The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of AbstractsBelgrade : Materials Research Society of Serbia., null, 68-68. 
Ignjatović Nenad, Ajduković Zorica, Drmanić Saša Ž., Uskoković Dragan, "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3" null (2011):68-68

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