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dc.creatorIgnjatović, Nenad
dc.creatorNinkov, Petar
dc.creatorSabetrasekh, Roya
dc.creatorLyngstadaas, Staale Petter
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2014
dc.identifier.issn0959-2989 (Print)
dc.identifier.issn1878-3619 (Online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/653
dc.description.abstractMost drug delivery systems as treatment modalities for osteomyelitis have not been evaluated for resistant infections. Tigecycline (TG) is an antimicrobial agent that could be used in the treatment of multi-drug-resistant orthopedic infections. The objective of this in vitro study has been to determine what dosage of TG causes changes in the morphology and number of osteoblasts. We have also investigated whether nanoparticulate tigecycline-loaded calcium-phosphate/poly-DL-lactide-co-glycolide is biocompatible and whether it could release bioactive TG in a controlled manner during the observation time. The cytotoxicity was tested by analyzing the release of lactate dehydrogenase from dead osteoblasts to the medium. Staphylococcus aureus was used to verify the antibacterial effect of the multifunctional drug delivery system. At concentrations as achieved by local application, TG caused high toxic effect and impaired the normal osteoblastic morphology. The nanoparticulate multifunctional drug delivery system showed good compatibility and antibacterial effect during the observation time and thus appears to be suitable for the treatment of osteomyelitis caused by multi-drug-resistant microbes.en
dc.languageen
dc.publisherIOS Press
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsrestrictedAccess
dc.sourceBio-Medical Materials and Engineeringen
dc.subjectcalcium phosphate
dc.subjectdrug delivery
dc.subjectnanomaterials
dc.subjectpoly-DL-lactide-co-glycolide
dc.titleIn vitro evaluation of a multifunctional nano drug delivery system based on tigecycline-loaded calcium-phosphate/ poly-DL-lactide-co-glycolideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИгњатовић, Ненад; Лyнгстадаас, Стаале Петтер; Ускоковић, Драган; Нинков, Петар; Сабетрасекх, Роyа;
dc.citation.spage1647
dc.citation.epage1658
dc.citation.volume24
dc.citation.issue4
dc.identifier.wos000337913300001
dc.identifier.doi10.3233/BME-140978
dc.identifier.pmid24948450
dc.identifier.scopus2-s2.0-84908664255
dc.description.otherPeer-reviewed manuscript: [http://dais.sanu.ac.rs/123456789/538]
dc.type.versionpublishedVersion


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