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In vitro evaluation of a multifunctional nano drug delivery system based on tigecycline-loaded calcium-phosphate/ poly-DL-lactide-co-glycolide

Authorized Users Only
2014
Authors
Ignjatović, Nenad
Ninkov, Petar
Sabetrasekh, Roya
Lyngstadaas, Staale Petter
Uskoković, Dragan
Article (Published version)
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Abstract
Most drug delivery systems as treatment modalities for osteomyelitis have not been evaluated for resistant infections. Tigecycline (TG) is an antimicrobial agent that could be used in the treatment of multi-drug-resistant orthopedic infections. The objective of this in vitro study has been to determine what dosage of TG causes changes in the morphology and number of osteoblasts. We have also investigated whether nanoparticulate tigecycline-loaded calcium-phosphate/poly-DL-lactide-co-glycolide is biocompatible and whether it could release bioactive TG in a controlled manner during the observation time. The cytotoxicity was tested by analyzing the release of lactate dehydrogenase from dead osteoblasts to the medium. Staphylococcus aureus was used to verify the antibacterial effect of the multifunctional drug delivery system. At concentrations as achieved by local application, TG caused high toxic effect and impaired the normal osteoblastic morphology. The nanoparticulate multifunctional ...drug delivery system showed good compatibility and antibacterial effect during the observation time and thus appears to be suitable for the treatment of osteomyelitis caused by multi-drug-resistant microbes.

Keywords:
calcium phosphate / drug delivery / nanomaterials / poly-DL-lactide-co-glycolide
Source:
Bio-Medical Materials and Engineering, 2014, 24, 4, 1647-1658
Publisher:
  • IOS Press
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
Note:
  • Peer-reviewed manuscript: http://dais.sanu.ac.rs/123456789/538

DOI: 10.3233/BME-140978

ISSN: 0959-2989 (Print); 1878-3619 (Online)

PubMed: 24948450

WoS: 000337913300001

Scopus: 2-s2.0-84908664255
[ Google Scholar ]
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URI
http://dais.sanu.ac.rs/123456789/653
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences SASA

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