Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells
Authors
Janićijević, JelenaNajman, Stevo

Vukelić, Marija
Ignjatović, Nenad

Uskoković, Dragan

Đorđević, Ljubiša
Vasiljević, Perica

Conference object (Published version)
Metadata
Show full item recordAbstract
Hydroxyapatite (HAp) is biomaterial widely used in the regeneration of bone tissue.
Addition of osteogenic cells to HAp implants may accelerate the bone repair process. The aim of
this study was to investigate how the bone marrow cells (BMCs) loading of porous
hydroxyapatite/poly-L-lactide (HAp/PLLA) act to ectopic osteogenesis. In this purpose
HAp/PLLA with and without BMCs was subcutaneously implanted into BALB/c mice. As a
control served implants from both types which weren’t implanted. Three weeks after
implantation, histological analysis of implants was done. It was observed significant resorption
and induction of collagenogenesis in implanted biomaterials. The structure of new bone was
seen in implants loaded with bone marrow cells.
Keywords:
hydroxyapatite (HAp) / bone marrow cells (BMCs) / implanted biomaterials / Hidroksipatit (Hap) / ćelije koštane srži / implantirani biomaterijaliSource:
Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007, 2007, 181-181Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Regeneracija skeletnih tkiva pomognuta biomaterijalima kao tkivnim matricama - in vivo i in vitro studija (RS-145072)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Janićijević, Jelena AU - Najman, Stevo AU - Vukelić, Marija AU - Ignjatović, Nenad AU - Uskoković, Dragan AU - Đorđević, Ljubiša AU - Vasiljević, Perica PY - 2007 UR - 181 UR - https://dais.sanu.ac.rs/123456789/6283 AB - Hydroxyapatite (HAp) is biomaterial widely used in the regeneration of bone tissue. Addition of osteogenic cells to HAp implants may accelerate the bone repair process. The aim of this study was to investigate how the bone marrow cells (BMCs) loading of porous hydroxyapatite/poly-L-lactide (HAp/PLLA) act to ectopic osteogenesis. In this purpose HAp/PLLA with and without BMCs was subcutaneously implanted into BALB/c mice. As a control served implants from both types which weren’t implanted. Three weeks after implantation, histological analysis of implants was done. It was observed significant resorption and induction of collagenogenesis in implanted biomaterials. The structure of new bone was seen in implants loaded with bone marrow cells. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007 T1 - Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells SP - 181 EP - 181 UR - https://hdl.handle.net/21.15107/rcub_dais_6283 ER -
@conference{ author = "Janićijević, Jelena and Najman, Stevo and Vukelić, Marija and Ignjatović, Nenad and Uskoković, Dragan and Đorđević, Ljubiša and Vasiljević, Perica", year = "2007", abstract = "Hydroxyapatite (HAp) is biomaterial widely used in the regeneration of bone tissue. Addition of osteogenic cells to HAp implants may accelerate the bone repair process. The aim of this study was to investigate how the bone marrow cells (BMCs) loading of porous hydroxyapatite/poly-L-lactide (HAp/PLLA) act to ectopic osteogenesis. In this purpose HAp/PLLA with and without BMCs was subcutaneously implanted into BALB/c mice. As a control served implants from both types which weren’t implanted. Three weeks after implantation, histological analysis of implants was done. It was observed significant resorption and induction of collagenogenesis in implanted biomaterials. The structure of new bone was seen in implants loaded with bone marrow cells.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007", title = "Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells", pages = "181-181", url = "https://hdl.handle.net/21.15107/rcub_dais_6283" }
Janićijević, J., Najman, S., Vukelić, M., Ignjatović, N., Uskoković, D., Đorđević, L.,& Vasiljević, P.. (2007). Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007 Belgrade : Institute of Technical Sciences of SASA., 181-181. https://hdl.handle.net/21.15107/rcub_dais_6283
Janićijević J, Najman S, Vukelić M, Ignjatović N, Uskoković D, Đorđević L, Vasiljević P. Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007. 2007;:181-181. https://hdl.handle.net/21.15107/rcub_dais_6283 .
Janićijević, Jelena, Najman, Stevo, Vukelić, Marija, Ignjatović, Nenad, Uskoković, Dragan, Đorđević, Ljubiša, Vasiljević, Perica, "Osteogenic activity in a mice subcutaneous implant of porous hydroxyapatite/poly-L-lactide loaded with bone marrow cells" in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007 (2007):181-181, https://hdl.handle.net/21.15107/rcub_dais_6283 .