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PDLLA microparticles containing BSA: effect of formulation variables on size distribution

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2007
bitstream_19680.pdf (236.3Kb)
Authors
Jovanović, Ivana
Petković, Marijana
Jordović, Branka
Ignjatović, Nenad
Uskoković, Dragan
Conference object (Published version)
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Abstract
Worldwide, there is u currently considerable care for the development of biodegradable microspheres as systems for controlled release of medicaments. The major disadvantage of traditional administration routes of medicaments is the need for frequent repetition. Encapsulation has been proven to be an effective vehicle for the controlled delivery of various medicaments. The encapsulation efficiency and release kinetics of the medicaments have been found to be dependent upon the size of the microspheres synthesized. The aim of this study was to formulate microparticles from poly-dl-lactide (PDLLA) by modified precipitation method. Bovine serum albumin (BSA) was used as a model protein for encapsulation. The surfactant polyvinyl alcohol (PVA) was incorporated to increase encapsulation efficiency and to achieve PDLLA spheres with desired size. The main focus was to study the effect of co-solvent selection (methanol or ethanol), PVA concentration, chloroform-to-water ratio, the spe...ed and time of homogenization and solvent removal rate on the properties of microparticles. The average size and morphology of microparticles varied substantially among these preparation conditions. An increase in stirring rate and time of homogenization and concentration of stabilizer agent were found to reduce moderately the size of microparticles. Other process parameters had limited influence on particle size.

Keywords:
poly-dl-lactide (PDLLA) / bovine serum albumin (BSA) / polyvinyl alcohol (PVA) / poli-DL-laktid / goveđi serumski albumin / polivinil-alkohol
Source:
Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007, 2007, 170-170
Publisher:
  • Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
  • Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)

ISBN: 9788680321110

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_6282
URI
https://dais.sanu.ac.rs/123456789/6282
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Jovanović, Ivana
AU  - Petković, Marijana
AU  - Jordović, Branka
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2007
UR  - https://dais.sanu.ac.rs/123456789/6282
AB  - Worldwide, there is u currently considerable care for the development of
biodegradable microspheres as systems for controlled release of medicaments. The major
disadvantage of traditional administration routes of medicaments is the need for frequent
repetition. Encapsulation has been proven to be an effective vehicle for the controlled delivery
of various medicaments. The encapsulation efficiency and release kinetics of the medicaments
have been found to be dependent upon the size of the microspheres synthesized. The aim of this
study was to formulate microparticles from poly-dl-lactide (PDLLA) by modified precipitation
method. Bovine serum albumin (BSA) was used as a model protein for encapsulation. The
surfactant polyvinyl alcohol (PVA) was incorporated to increase encapsulation efficiency and to
achieve PDLLA spheres with desired size. The main focus was to study the effect of co-solvent
selection (methanol or ethanol), PVA concentration, chloroform-to-water ratio, the speed and
time of homogenization and solvent removal rate on the properties of microparticles. The
average size and morphology of microparticles varied substantially among these preparation
conditions. An increase in stirring rate and time of homogenization and concentration of
stabilizer agent were found to reduce moderately the size of microparticles. Other process
parameters had limited influence on particle size.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007
T1  - PDLLA microparticles containing BSA: effect of formulation variables on size distribution
SP  - 170
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_dais_6282
ER  - 
@conference{
author = "Jovanović, Ivana and Petković, Marijana and Jordović, Branka and Ignjatović, Nenad and Uskoković, Dragan",
year = "2007",
abstract = "Worldwide, there is u currently considerable care for the development of
biodegradable microspheres as systems for controlled release of medicaments. The major
disadvantage of traditional administration routes of medicaments is the need for frequent
repetition. Encapsulation has been proven to be an effective vehicle for the controlled delivery
of various medicaments. The encapsulation efficiency and release kinetics of the medicaments
have been found to be dependent upon the size of the microspheres synthesized. The aim of this
study was to formulate microparticles from poly-dl-lactide (PDLLA) by modified precipitation
method. Bovine serum albumin (BSA) was used as a model protein for encapsulation. The
surfactant polyvinyl alcohol (PVA) was incorporated to increase encapsulation efficiency and to
achieve PDLLA spheres with desired size. The main focus was to study the effect of co-solvent
selection (methanol or ethanol), PVA concentration, chloroform-to-water ratio, the speed and
time of homogenization and solvent removal rate on the properties of microparticles. The
average size and morphology of microparticles varied substantially among these preparation
conditions. An increase in stirring rate and time of homogenization and concentration of
stabilizer agent were found to reduce moderately the size of microparticles. Other process
parameters had limited influence on particle size.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007",
title = "PDLLA microparticles containing BSA: effect of formulation variables on size distribution",
pages = "170-170",
url = "https://hdl.handle.net/21.15107/rcub_dais_6282"
}
Jovanović, I., Petković, M., Jordović, B., Ignjatović, N.,& Uskoković, D.. (2007). PDLLA microparticles containing BSA: effect of formulation variables on size distribution. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007
Belgrade : Institute of Technical Sciences of SASA., 170-170.
https://hdl.handle.net/21.15107/rcub_dais_6282
Jovanović I, Petković M, Jordović B, Ignjatović N, Uskoković D. PDLLA microparticles containing BSA: effect of formulation variables on size distribution. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007. 2007;:170-170.
https://hdl.handle.net/21.15107/rcub_dais_6282 .
Jovanović, Ivana, Petković, Marijana, Jordović, Branka, Ignjatović, Nenad, Uskoković, Dragan, "PDLLA microparticles containing BSA: effect of formulation variables on size distribution" in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007 (2007):170-170,
https://hdl.handle.net/21.15107/rcub_dais_6282 .

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