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dc.creatorStevanović, Magdalena
dc.creatorNunić, Jana
dc.creatorChoi, Jonghoon
dc.creatorFilipović, Miloš
dc.creatorUskoković, Dragan
dc.creatorTsotakos, Theodore
dc.creatorFragogeorgi, Eirini
dc.creatorPsimadas, Dimitris
dc.creatorPalamaris, Lazaros
dc.creatorLoudos, George
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2014
dc.identifier.urihttps://dais.sanu.ac.rs/123456789/584
dc.description.abstractSelenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.en
dc.format(2014) 38-38
dc.formatapplication/pdf
dc.languageen
dc.publisherBelgrade : Materials Research Society of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceThe Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstractsen
dc.subjectselenium nanoparticles
dc.subjectpoly (DL-lactide-co-glycolide)
dc.subjectanticancer activity
dc.titlePoly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionalityen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractПсимадас, Димитрис; Тсотакос, Тхеодоре; Ускоковић, Драган; Филиповић, Милош; Цхои, Јонгхоон; Нунић, Јана; Стевановић, Магдалена; Лоудос, Георге; Паламарис, Лазарос; Фрагогеорги, Еирини;
dc.citation.spage38
dc.citation.epage38
dc.type.versionpublishedVersion
dc.identifier.fulltexthttps://dais.sanu.ac.rs/bitstream/id/21555/581.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_dais_584


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