DAIS - Digital Archive of the Serbian Academy of Sciences and Arts
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality

Thumbnail
2014
581.pdf (133.2Kb)
Authors
Stevanović, Magdalena
Nunić, Jana
Choi, Jonghoon
Filipović, Miloš
Uskoković, Dragan
Tsotakos, Theodore
Fragogeorgi, Eirini
Psimadas, Dimitris
Palamaris, Lazaros
Loudos, George
Conference object (Published version)
Metadata
Show full item record
Abstract
Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparti...cles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.

Keywords:
selenium nanoparticles / poly (DL-lactide-co-glycolide) / anticancer activity
Source:
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts, 2014, 38-38
Publisher:
  • Belgrade : Materials Research Society of Serbia
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_584
URI
https://dais.sanu.ac.rs/123456789/584
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Stevanović, Magdalena
AU  - Nunić, Jana
AU  - Choi, Jonghoon
AU  - Filipović, Miloš
AU  - Uskoković, Dragan
AU  - Tsotakos, Theodore
AU  - Fragogeorgi, Eirini
AU  - Psimadas, Dimitris
AU  - Palamaris, Lazaros
AU  - Loudos, George
PY  - 2014
UR  - https://dais.sanu.ac.rs/123456789/584
AB  - Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
T1  - Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality
SP  - 38
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_dais_584
ER  - 
@conference{
author = "Stevanović, Magdalena and Nunić, Jana and Choi, Jonghoon and Filipović, Miloš and Uskoković, Dragan and Tsotakos, Theodore and Fragogeorgi, Eirini and Psimadas, Dimitris and Palamaris, Lazaros and Loudos, George",
year = "2014",
abstract = "Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparticles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts",
title = "Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality",
pages = "38-38",
url = "https://hdl.handle.net/21.15107/rcub_dais_584"
}
Stevanović, M., Nunić, J., Choi, J., Filipović, M., Uskoković, D., Tsotakos, T., Fragogeorgi, E., Psimadas, D., Palamaris, L.,& Loudos, G.. (2014). Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 38-38.
https://hdl.handle.net/21.15107/rcub_dais_584
Stevanović M, Nunić J, Choi J, Filipović M, Uskoković D, Tsotakos T, Fragogeorgi E, Psimadas D, Palamaris L, Loudos G. Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:38-38.
https://hdl.handle.net/21.15107/rcub_dais_584 .
Stevanović, Magdalena, Nunić, Jana, Choi, Jonghoon, Filipović, Miloš, Uskoković, Dragan, Tsotakos, Theodore, Fragogeorgi, Eirini, Psimadas, Dimitris, Palamaris, Lazaros, Loudos, George, "Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):38-38,
https://hdl.handle.net/21.15107/rcub_dais_584 .

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

CoreTrustSealre3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

CoreTrustSealre3dataOpenAIRERCUB