DAIS - Digital Archive of the Serbian Academy of Sciences and Arts
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences SASA
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
  • View Item
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences SASA
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Poly (DL-lactide-co-glycolide) nanospheres with encapsulated selenium nanoparticles as a system with therapeutic functionality

Thumbnail
2014
581.pdf (133.2Kb)
Authors
Stevanović, Magdalena
Nunić, Jana
Choi, Jonghoon
Filipović, Miloš
Uskoković, Dragan
Tsotakos, Theodore
Fragogeorgi, Eirini
Psimadas, Dimitris
Palamaris, Lazaros
Loudos, George
Conference object (Published version)
Metadata
Show full item record
Abstract
Selenium (Se) is an essential trace element with important physiological functions and extensive pharmacological actions. The role of selenium as a chemopreventive and chemotherapeutic agent has been supported by a large number of epidemiological, preclinical, and clinical trials. Uniform, stable, amorphous selenium nanoparticles (SeNps) have been synthesized and additionally encapsulated within spherical PLGA particles (PLGA/SeNps). The morphology (size and shape) of the particles plays key role in their adhesion and interaction with the cell. Synthesized particles were characterized by FTIR spectroscopy, FESEM, TEM, HRTEM, and Zeta potential measurements. The influence of PLGA/SeNps on cell viability, ROS generation in HepG2 cells, as well as anticancer activity against epithelial tumor cells was investigated. As a part of this study, we have also performed in vivo dynamic imaging studies in normal mice, using SPECT imaging and a high resolution gamma camera. The PLGA/SeNps nanoparti...cles have been radiolabelled with Tc-99m, by applying the direct labeling method. Ex vivo biodistribution measurements, as well as in vivo dynamic studies up to 1h p.i. and at 24h were performed, showing increased concentration in liver and spleen.

Keywords:
selenium nanoparticles / poly (DL-lactide-co-glycolide) / anticancer activity
Source:
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts, 2014, 38-38
Publisher:
  • Belgrade : Materials Research Society of Serbia
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/584
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences SASA

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

re3dataOpenAIRERCUB