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Interaction of nanoparticles and biological fluids

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2014
555.pdf (127.2Kb)
Authors
Ajduković, Zorica
Ignjatović, Nenad
Petrović, Nenad
Rajković, Jelena
Kenić Marinković, Dragana
Najman, Stevo
Mihailović, Dragan
Uskoković, Dragan
Conference object (Published version)
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Abstract
Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.
Keywords:
nanoparticles / biological fluids / spectrophotometery
Source:
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts, 2014, 113-113
Publisher:
  • Belgrade : Materials Research Society of Serbia
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
  • Virtual human osteoarticular system and its application in preclinical and clinical practice (RS-41017)
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_558
URI
https://dais.sanu.ac.rs/123456789/558
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Petrović, Nenad
AU  - Rajković, Jelena
AU  - Kenić Marinković, Dragana
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Uskoković, Dragan
PY  - 2014
UR  - https://dais.sanu.ac.rs/123456789/558
AB  - Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
T1  - Interaction of nanoparticles and biological fluids
SP  - 113
EP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_dais_558
ER  - 
@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Nenad and Rajković, Jelena and Kenić Marinković, Dragana and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan",
year = "2014",
abstract = "Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts",
title = "Interaction of nanoparticles and biological fluids",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_dais_558"
}
Ajduković, Z., Ignjatović, N., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, S., Mihailović, D.,& Uskoković, D.. (2014). Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 113-113.
https://hdl.handle.net/21.15107/rcub_dais_558
Ajduković Z, Ignjatović N, Petrović N, Rajković J, Kenić Marinković D, Najman S, Mihailović D, Uskoković D. Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:113-113.
https://hdl.handle.net/21.15107/rcub_dais_558 .
Ajduković, Zorica, Ignjatović, Nenad, Petrović, Nenad, Rajković, Jelena, Kenić Marinković, Dragana, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Interaction of nanoparticles and biological fluids" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):113-113,
https://hdl.handle.net/21.15107/rcub_dais_558 .

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