Interaction of nanoparticles and biological fluids

2014
Authors
Ajduković, Zorica
Ignjatović, Nenad

Petrović, Nenad
Rajković, Jelena
Kenić Marinković, Dragana
Najman, Stevo

Mihailović, Dragan
Uskoković, Dragan

Conference object (Published version)
Metadata
Show full item recordAbstract
Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.
Keywords:
nanoparticles / biological fluids / spectrophotometerySource:
The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts, 2014, 113-113Publisher:
- Belgrade : Materials Research Society of Serbia
Funding / projects:
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
- Virtual human osteoarticular system and its application in preclinical and clinical practice (RS-41017)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ajduković, Zorica AU - Ignjatović, Nenad AU - Petrović, Nenad AU - Rajković, Jelena AU - Kenić Marinković, Dragana AU - Najman, Stevo AU - Mihailović, Dragan AU - Uskoković, Dragan PY - 2014 UR - https://dais.sanu.ac.rs/123456789/558 AB - Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery. PB - Belgrade : Materials Research Society of Serbia C3 - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts T1 - Interaction of nanoparticles and biological fluids SP - 113 EP - 113 UR - https://hdl.handle.net/21.15107/rcub_dais_558 ER -
@conference{ author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Nenad and Rajković, Jelena and Kenić Marinković, Dragana and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan", year = "2014", abstract = "Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts", title = "Interaction of nanoparticles and biological fluids", pages = "113-113", url = "https://hdl.handle.net/21.15107/rcub_dais_558" }
Ajduković, Z., Ignjatović, N., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, S., Mihailović, D.,& Uskoković, D.. (2014). Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 113-113. https://hdl.handle.net/21.15107/rcub_dais_558
Ajduković Z, Ignjatović N, Petrović N, Rajković J, Kenić Marinković D, Najman S, Mihailović D, Uskoković D. Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:113-113. https://hdl.handle.net/21.15107/rcub_dais_558 .
Ajduković, Zorica, Ignjatović, Nenad, Petrović, Nenad, Rajković, Jelena, Kenić Marinković, Dragana, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Interaction of nanoparticles and biological fluids" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):113-113, https://hdl.handle.net/21.15107/rcub_dais_558 .