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TY - JOUR
AU - Janićijević, Željko
AU - Ninkov, Marina
AU - Kataranovski, Milena
AU - Radovanović, Filip
PY - 2019
UR - https://dais.sanu.ac.rs/123456789/5253
AB - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PB - Wiley
T2 - Macromolecular Bioscience
T1 - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
SP - 1800322
VL - 19
DO - 10.1002/mabi.201800322
UR - https://hdl.handle.net/21.15107/rcub_dais_5253
ER -
@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2019",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
publisher = "Wiley",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs",
pages = "1800322",
volume = "19",
doi = "10.1002/mabi.201800322",
url = "https://hdl.handle.net/21.15107/rcub_dais_5253"
}
Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F.. (2019). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience
Wiley., 19, 1800322.
https://doi.org/10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_5253
Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience. 2019;19:1800322.
doi:10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_5253 .
Janićijević, Željko, Ninkov, Marina, Kataranovski, Milena, Radovanović, Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs" in Macromolecular Bioscience, 19 (2019):1800322,
https://doi.org/10.1002/mabi.201800322 .,
https://hdl.handle.net/21.15107/rcub_dais_5253 .
