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Tailored preparation of nano and micro composites as new controlled bone drug delivery systems

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2009
Ignjatovic_12-Ceramics-Cells-Tissues_2009.pdf (239.9Kb)
Authors
Ignjatović, Nenad
Stevanović, Magdalena
Vukomanović, Marija
Uskoković, Dragan
Conference object (Published version)
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Abstract
Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in ...solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.

Keywords:
controlled drug delivery / sonochemistry / composite biomaterials / bone
Source:
Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting, 2009, 60-60
Publisher:
  • Faenza : ISTEC-CNR
Funding / projects:
  • Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_4935
URI
https://dais.sanu.ac.rs/123456789/4935
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Ignjatović, Nenad
AU  - Stevanović, Magdalena
AU  - Vukomanović, Marija
AU  - Uskoković, Dragan
PY  - 2009
UR  - https://dais.sanu.ac.rs/123456789/4935
AB  - Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.
PB  - Faenza : ISTEC-CNR
C3  - Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting
T1  - Tailored preparation of nano and micro composites as new controlled bone drug delivery systems
SP  - 60
EP  - 60
UR  - https://hdl.handle.net/21.15107/rcub_dais_4935
ER  - 
@conference{
author = "Ignjatović, Nenad and Stevanović, Magdalena and Vukomanović, Marija and Uskoković, Dragan",
year = "2009",
abstract = "Method of homogenous sonochemical principle for obtaining controlled forms of micro/nano particles of desired shapes, size and distribution, and solvent/nonsolvent method for obtaining spherical particles of polymer or polymer/ceramics composites with the encapsulated pharmacologically active agent for the treatment of bone tissue pathology, are methods developed in our laboratory for the production of nano and micro ceramic/polymer or polymer composite systems which can be potentially used as controlled bone drug delivery system. Method of homogenous sonochemical precipitation, by designing synthesis parameters like temperature, frequency, energy and ultrasonic field regime, and by applying appropriate solvents, enables producing desired forms and particle structures. Through this method calcium phosphate systems can be obtained, but also systems where calcium phosphate particles are coated with bioresorbable polymer with immobilized antibiotic. Physicochemical synthesis procedure in solvent/non-solvent method consists of initial dissolve of desired bioresorbable polymers and its homogenization, followed by encapsulation of the desired agents. Already produced pharmaceutically active compounds (ascorbic, folic acid, peroxidase, antibiotics, autologous plasma, etc.) can be encapsulated or different calcium phosphates used as fillers for the defected bone tissue. Micro, submicro and nano sized particles in deagglomeration form, optimal for the advanced application in bone engineering, are obtained through these preparation methods.",
publisher = "Faenza : ISTEC-CNR",
journal = "Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting",
title = "Tailored preparation of nano and micro composites as new controlled bone drug delivery systems",
pages = "60-60",
url = "https://hdl.handle.net/21.15107/rcub_dais_4935"
}
Ignjatović, N., Stevanović, M., Vukomanović, M.,& Uskoković, D.. (2009). Tailored preparation of nano and micro composites as new controlled bone drug delivery systems. in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting
Faenza : ISTEC-CNR., 60-60.
https://hdl.handle.net/21.15107/rcub_dais_4935
Ignjatović N, Stevanović M, Vukomanović M, Uskoković D. Tailored preparation of nano and micro composites as new controlled bone drug delivery systems. in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting. 2009;:60-60.
https://hdl.handle.net/21.15107/rcub_dais_4935 .
Ignjatović, Nenad, Stevanović, Magdalena, Vukomanović, Marija, Uskoković, Dragan, "Tailored preparation of nano and micro composites as new controlled bone drug delivery systems" in Abastracts / Ceramics, cells and tissues: 12th annual seminar and meeting (2009):60-60,
https://hdl.handle.net/21.15107/rcub_dais_4935 .

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