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Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles

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2009
bitstream_15425.pdf (356.0Kb)
Authors
Ajduković, Zorica
Ignjatović, Nenad
Stojanović, Zoran S.
Kaličanin, Biljana
Savić, Vojin
Petrović, S. M.
Petrović, B. M.
Milićević, Jelena
Uskoković, Dragan
Conference object (Published version)
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Abstract
In this study nanocomposite was used for reconstruction of alveolar bone defect of mandible. Specifically, the main interest for the use of magnetic nanoparticles in biomedical applications is that an inhomogeneous external magnetic field exerts a force on them, and thus they can be manipulated or transported to a specific diseased tissue by a magnetic field gradient. In addition, magnetic particles are of interest because they do not retain any magnetism after removal of the magnetic field. Specifically, inorganic biodegradable nanoparticles (including ceramics, like hydroxyapatite) will be functionalized with bioactive compounds that bond to bone of low mass. Extremely good results in the recovery of alveolar bone osteoporosis were achieved already after 6th week of the application of magnetic nanoparticles. After bonding specifically to osteoporotic bone and not healthy bone, magnetic nanoparticle systems will deliver bioactive compounds to locally increase bone mass. Implantation o...f magnetic nanoparticles will create bone construction and enable quick formation of new bone and become the material of choice for accelerated bone regeneration.

Keywords:
osteoporosis / Ca/Co-HAp / magnetic nanoparticles / biomedical materials
Source:
Programme and The Book of Abstracts / Eleventh Annual Conference YUCOMAT 2009, Herceg Novi, August 31 – September 4, 2009, 2009, 188-188
Publisher:
  • Belgrade : Institute of Technical Sciences of SASA
Projects:
  • Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
  • Biokompatibilnost i mogućnosti primene biomaterijala na bazi hidroksiapatita i biopolimera u tkivnoj reparaciji - eksperimentalna i klinička studija (RS-145068)

ISBN: 978-86-80321-18-9

[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/4934
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Stojanović, Zoran S.
AU  - Kaličanin, Biljana
AU  - Savić, Vojin
AU  - Petrović, S. M.
AU  - Petrović, B. M.
AU  - Milićević, Jelena
AU  - Uskoković, Dragan
PY  - 2009
UR  - http://dais.sanu.ac.rs/123456789/4934
AB  - In this study nanocomposite was used for reconstruction of alveolar bone defect of mandible. Specifically, the main interest for the use of magnetic nanoparticles in biomedical applications is that an inhomogeneous external magnetic field exerts a force on them, and thus they can be manipulated or transported to a specific diseased tissue by a magnetic field gradient. In addition, magnetic particles are of interest because they do not retain any magnetism after removal of the magnetic field. Specifically, inorganic biodegradable nanoparticles (including ceramics, like hydroxyapatite) will be functionalized with bioactive compounds that bond to bone of low mass. Extremely good results in the recovery of alveolar bone osteoporosis were achieved already after 6th week of the application of magnetic nanoparticles. After bonding specifically to osteoporotic bone and not healthy bone, magnetic nanoparticle systems will deliver bioactive compounds to locally increase bone mass. Implantation of magnetic nanoparticles will create bone construction and enable quick formation of new bone and become the material of choice for accelerated bone regeneration.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Programme and The Book of Abstracts / Eleventh Annual Conference YUCOMAT 2009, Herceg Novi, August 31 – September 4, 2009
T1  - Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles
SP  - 188
EP  - 188
ER  - 
@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad and Stojanović, Zoran S. and Kaličanin, Biljana and Savić, Vojin and Petrović, S. M. and Petrović, B. M. and Milićević, Jelena and Uskoković, Dragan",
year = "2009",
url = "http://dais.sanu.ac.rs/123456789/4934",
abstract = "In this study nanocomposite was used for reconstruction of alveolar bone defect of mandible. Specifically, the main interest for the use of magnetic nanoparticles in biomedical applications is that an inhomogeneous external magnetic field exerts a force on them, and thus they can be manipulated or transported to a specific diseased tissue by a magnetic field gradient. In addition, magnetic particles are of interest because they do not retain any magnetism after removal of the magnetic field. Specifically, inorganic biodegradable nanoparticles (including ceramics, like hydroxyapatite) will be functionalized with bioactive compounds that bond to bone of low mass. Extremely good results in the recovery of alveolar bone osteoporosis were achieved already after 6th week of the application of magnetic nanoparticles. After bonding specifically to osteoporotic bone and not healthy bone, magnetic nanoparticle systems will deliver bioactive compounds to locally increase bone mass. Implantation of magnetic nanoparticles will create bone construction and enable quick formation of new bone and become the material of choice for accelerated bone regeneration.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Programme and The Book of Abstracts / Eleventh Annual Conference YUCOMAT 2009, Herceg Novi, August 31 – September 4, 2009",
title = "Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles",
pages = "188-188"
}
Ajduković Z, Ignjatović N, Stojanović ZS, Kaličanin B, Savić V, Petrović SM, Petrović BM, Milićević J, Uskoković D. Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles. Programme and The Book of Abstracts / Eleventh Annual Conference YUCOMAT 2009, Herceg Novi, August 31 – September 4, 2009. 2009;:188-188
Ajduković, Z., Ignjatović, N., Stojanović, Z. S., Kaličanin, B., Savić, V., Petrović, S. M., Petrović, B. M., Milićević, J.,& Uskoković, D. (2009). Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles.
Programme and The Book of Abstracts / Eleventh Annual Conference YUCOMAT 2009, Herceg Novi, August 31 – September 4, 2009Belgrade : Institute of Technical Sciences of SASA., null, 188-188. 
Ajduković Zorica, Ignjatović Nenad, Stojanović Zoran S., Kaličanin Biljana, Savić Vojin, Petrović S. M., Petrović B. M., Milićević Jelena, Uskoković Dragan, "Treatment of osteoporosis alveolar bone with cobalt substituted hydroxyapatite nanoparticles" null (2009):188-188

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