Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid
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2012
Authors
Vukelić, Marija Đ.
Mitić, Žarko
Miljković, Miroslav
Živković, Jelena M.
Ignjatović, Nenad

Uskoković, Dragan

Živanov Čurlis, Jelena Z.
Vasiljević, Perica

Najman, Stevo

Article (Published version)

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Show full item recordAbstract
Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considere...d crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.
Keywords:
calcium phosphate and poly-DL-lactide-co-glycolide / simulated body fluid / bioceramicsSource:
Journal of Applied Biomaterials and Functional Materials, 2012, 43-48Publisher:
- Milano : Wichtig Publishing
Funding / projects:
- Virtual human osteoarticular system and its application in preclinical and clinical practice (RS-41017)
DOI: 10.5301/JABFM.2012.9274
ISSN: 2280-8000
WoS: 000309586600007
Scopus: 2-s2.0-84863962495
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Vukelić, Marija Đ. AU - Mitić, Žarko AU - Miljković, Miroslav AU - Živković, Jelena M. AU - Ignjatović, Nenad AU - Uskoković, Dragan AU - Živanov Čurlis, Jelena Z. AU - Vasiljević, Perica AU - Najman, Stevo PY - 2012 UR - https://dais.sanu.ac.rs/123456789/489 AB - Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration. PB - Milano : Wichtig Publishing T2 - Journal of Applied Biomaterials and Functional Materials T1 - Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid SP - 43 EP - 48 DO - 10.5301/JABFM.2012.9274 UR - https://hdl.handle.net/21.15107/rcub_dais_489 ER -
@article{ author = "Vukelić, Marija Đ. and Mitić, Žarko and Miljković, Miroslav and Živković, Jelena M. and Ignjatović, Nenad and Uskoković, Dragan and Živanov Čurlis, Jelena Z. and Vasiljević, Perica and Najman, Stevo", year = "2012", abstract = "Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.", publisher = "Milano : Wichtig Publishing", journal = "Journal of Applied Biomaterials and Functional Materials", title = "Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid", pages = "43-48", doi = "10.5301/JABFM.2012.9274", url = "https://hdl.handle.net/21.15107/rcub_dais_489" }
Vukelić, M. Đ., Mitić, Ž., Miljković, M., Živković, J. M., Ignjatović, N., Uskoković, D., Živanov Čurlis, J. Z., Vasiljević, P.,& Najman, S.. (2012). Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid. in Journal of Applied Biomaterials and Functional Materials Milano : Wichtig Publishing., 43-48. https://doi.org/10.5301/JABFM.2012.9274 https://hdl.handle.net/21.15107/rcub_dais_489
Vukelić MĐ, Mitić Ž, Miljković M, Živković JM, Ignjatović N, Uskoković D, Živanov Čurlis JZ, Vasiljević P, Najman S. Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid. in Journal of Applied Biomaterials and Functional Materials. 2012;:43-48. doi:10.5301/JABFM.2012.9274 https://hdl.handle.net/21.15107/rcub_dais_489 .
Vukelić, Marija Đ., Mitić, Žarko, Miljković, Miroslav, Živković, Jelena M., Ignjatović, Nenad, Uskoković, Dragan, Živanov Čurlis, Jelena Z., Vasiljević, Perica, Najman, Stevo, "Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid" in Journal of Applied Biomaterials and Functional Materials (2012):43-48, https://doi.org/10.5301/JABFM.2012.9274 ., https://hdl.handle.net/21.15107/rcub_dais_489 .