Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors
Abstract
We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.
Keywords:
Biosensor / competitive adsorption / mass transfer / adsorbed mass fluctuationsSource:
Procedia Engineering, 2012, 47, 957-960Publisher:
- Elsevier
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
DOI: 10.1016/j.proeng.2012.09.305
ISSN: 1877-7058
WoS: 000312953300236
Scopus: 2-s2.0-84891677032
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Frantlović, Miloš AU - Jokić, Ivana AU - Đurić, Zoran G. AU - Radulović, Katarina PY - 2012 UR - https://dais.sanu.ac.rs/123456789/4839 AB - We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement. PB - Elsevier C3 - Procedia Engineering T1 - Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors SP - 957 EP - 960 VL - 47 DO - 10.1016/j.proeng.2012.09.305 UR - https://hdl.handle.net/21.15107/rcub_dais_4839 ER -
@conference{ author = "Frantlović, Miloš and Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina", year = "2012", abstract = "We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.", publisher = "Elsevier", journal = "Procedia Engineering", title = "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors", pages = "957-960", volume = "47", doi = "10.1016/j.proeng.2012.09.305", url = "https://hdl.handle.net/21.15107/rcub_dais_4839" }
Frantlović, M., Jokić, I., Đurić, Z. G.,& Radulović, K.. (2012). Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors. in Procedia Engineering Elsevier., 47, 957-960. https://doi.org/10.1016/j.proeng.2012.09.305 https://hdl.handle.net/21.15107/rcub_dais_4839
Frantlović M, Jokić I, Đurić ZG, Radulović K. Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors. in Procedia Engineering. 2012;47:957-960. doi:10.1016/j.proeng.2012.09.305 https://hdl.handle.net/21.15107/rcub_dais_4839 .
Frantlović, Miloš, Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors" in Procedia Engineering, 47 (2012):957-960, https://doi.org/10.1016/j.proeng.2012.09.305 ., https://hdl.handle.net/21.15107/rcub_dais_4839 .