We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.
Keywords:
Biosensor / competitive adsorption / mass transfer / adsorbed mass fluctuations
TY - CONF
AU - Frantlović, Miloš
AU - Jokić, Ivana
AU - Đurić, Zoran G.
AU - Radulović, Katarina
PY - 2012
UR - http://dais.sanu.ac.rs/123456789/4839
AB - We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.
PB - Elsevier
C3 - Procedia Engineering
T1 - Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors
SP - 957
EP - 960
VL - 47
DO - 10.1016/j.proeng.2012.09.305
ER -
@conference{
author = "Frantlović, Miloš and Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina",
year = "2012",
url = "http://dais.sanu.ac.rs/123456789/4839",
abstract = "We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.",
publisher = "Elsevier",
journal = "Procedia Engineering",
title = "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors",
pages = "957-960",
volume = "47",
doi = "10.1016/j.proeng.2012.09.305"
}
Frantlović M, Jokić I, Đurić ZG, Radulović K. Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors. Procedia Engineering. 2012;47:957-960
Frantlović, M., Jokić, I., Đurić, Z. G.,& Radulović, K. (2012). Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors.
Procedia EngineeringElsevier., 47, 957-960.
https://doi.org/10.1016/j.proeng.2012.09.305
Frantlović Miloš, Jokić Ivana, Đurić Zoran G., Radulović Katarina, "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors" 47 (2012):957-960,
https://doi.org/10.1016/j.proeng.2012.09.305 .
