Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation
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Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and ...faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.
Keywords:
poly(lactic-co-glycolic acid)/poly(acrylic acid) / PLGA/PAA / composite implants / controlled drug delivery systems / gamma irradiation / UV irradiationSource:
Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia, 2018, 28-28Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Janićijević, Željko AU - Vujčić, Ivica T. AU - Vujisić, Miloš Lj. AU - Radovanović, Filip PY - 2018 UR - https://dais.sanu.ac.rs/123456789/4720 AB - Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia T1 - Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation SP - 28 EP - 28 UR - https://hdl.handle.net/21.15107/rcub_dais_4720 ER -
@conference{ author = "Janićijević, Željko and Vujčić, Ivica T. and Vujisić, Miloš Lj. and Radovanović, Filip", year = "2018", abstract = "Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia", title = "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation", pages = "28-28", url = "https://hdl.handle.net/21.15107/rcub_dais_4720" }
Janićijević, Ž., Vujčić, I. T., Vujisić, M. Lj.,& Radovanović, F.. (2018). Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation. in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia Belgrade : Institute of Technical Sciences of SASA., 28-28. https://hdl.handle.net/21.15107/rcub_dais_4720
Janićijević Ž, Vujčić IT, Vujisić ML, Radovanović F. Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation. in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia. 2018;:28-28. https://hdl.handle.net/21.15107/rcub_dais_4720 .
Janićijević, Željko, Vujčić, Ivica T., Vujisić, Miloš Lj., Radovanović, Filip, "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation" in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia (2018):28-28, https://hdl.handle.net/21.15107/rcub_dais_4720 .