Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes
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A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.
Keywords:
competitive adsorption / mass transfer / microfluidic sensor / stochastic time responseSource:
Proceedings, Volume 2, Eurosensors 2018, 2018, 2, 13, 991-Publisher:
- Basel : MDPI
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
- Serbian Academy of Sciences and Arts, Project F-150
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Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Jokić, Ivana AU - Đurić, Zoran G. AU - Radulović, Katarina AU - Frantlović, Miloš PY - 2018 UR - https://www.mdpi.com/2504-3900/2/13/991 UR - https://dais.sanu.ac.rs/123456789/4715 AB - A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples. PB - Basel : MDPI C3 - Proceedings, Volume 2, Eurosensors 2018 T1 - Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes SP - 991 VL - 2 IS - 13 DO - 10.3390/proceedings2130991 UR - https://hdl.handle.net/21.15107/rcub_dais_4715 ER -
@conference{ author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš", year = "2018", abstract = "A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.", publisher = "Basel : MDPI", journal = "Proceedings, Volume 2, Eurosensors 2018", title = "Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes", pages = "991", volume = "2", number = "13", doi = "10.3390/proceedings2130991", url = "https://hdl.handle.net/21.15107/rcub_dais_4715" }
Jokić, I., Đurić, Z. G., Radulović, K.,& Frantlović, M.. (2018). Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes. in Proceedings, Volume 2, Eurosensors 2018 Basel : MDPI., 2(13), 991. https://doi.org/10.3390/proceedings2130991 https://hdl.handle.net/21.15107/rcub_dais_4715
Jokić I, Đurić ZG, Radulović K, Frantlović M. Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes. in Proceedings, Volume 2, Eurosensors 2018. 2018;2(13):991. doi:10.3390/proceedings2130991 https://hdl.handle.net/21.15107/rcub_dais_4715 .
Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, "Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes" in Proceedings, Volume 2, Eurosensors 2018, 2, no. 13 (2018):991, https://doi.org/10.3390/proceedings2130991 ., https://hdl.handle.net/21.15107/rcub_dais_4715 .