The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.
TY - CONF
AU - Stojanović, S.
AU - Najman, Stevo
AU - Ajduković, Zorica
AU - Ignjatović, Nenad
AU - Uskoković, Dragan
PY - 2012
UR - https://dais.sanu.ac.rs/123456789/458
AB - The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.
PB - Belgrade : Materials Research Society of Serbia
C3 - The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
T1 - Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells
SP - 126
EP - 126
UR - https://hdl.handle.net/21.15107/rcub_dais_458
ER -
@conference{
author = "Stojanović, S. and Najman, Stevo and Ajduković, Zorica and Ignjatović, Nenad and Uskoković, Dragan",
year = "2012",
abstract = "The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts",
title = "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells",
pages = "126-126",
url = "https://hdl.handle.net/21.15107/rcub_dais_458"
}
Stojanović, S., Najman, S., Ajduković, Z., Ignjatović, N.,& Uskoković, D.. (2012). Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 126-126.
https://hdl.handle.net/21.15107/rcub_dais_458
Stojanović S, Najman S, Ajduković Z, Ignjatović N, Uskoković D. Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts. 2012;:126-126.
https://hdl.handle.net/21.15107/rcub_dais_458 .
Stojanović, S., Najman, Stevo, Ajduković, Zorica, Ignjatović, Nenad, Uskoković, Dragan, "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells" in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts (2012):126-126,
https://hdl.handle.net/21.15107/rcub_dais_458 .
