Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors
Abstract
We investigate the stochastic sensor response in equilibrium, taking into account competitive adsorption and mass transfer of analyte particles in a microfluidic biosensor chamber. After presentation of the stochastic model, we perform the analysis of the equilibrium response expected value as a function of the sensing area and the competitor molecules concentrations. By comparison with the deterministic value of the sensor response, the limits of applicability of the deterministic approach are investigated. The results of the presented analysis enable better interpretation of measurement results obtained by using sensors with micro/nanoscale sensing surface, as well as optimization of their design and operating conditions.
Keywords:
biosensors / competitive adsorption / deterministic time response / stochastic time responseSource:
Materials Today: Proceedings, 2018, 5, 8, Part 2, 16006-16011Publisher:
- Elsevier
Projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
DOI: 10.1016/j.matpr.2018.05.045
ISSN: 2214-7853
WoS: 000441006800008
Scopus: 2-s2.0-85056510161
URI
http://www.sciencedirect.com/science/article/pii/S2214785318309167http://dais.sanu.ac.rs/123456789/4550
TY - JOUR AU - Jokić, Ivana AU - Đurić, Zoran G. AU - Radulović, Katarina AU - Frantlović, Miloš PY - 2018 UR - http://www.sciencedirect.com/science/article/pii/S2214785318309167 UR - http://dais.sanu.ac.rs/123456789/4550 AB - We investigate the stochastic sensor response in equilibrium, taking into account competitive adsorption and mass transfer of analyte particles in a microfluidic biosensor chamber. After presentation of the stochastic model, we perform the analysis of the equilibrium response expected value as a function of the sensing area and the competitor molecules concentrations. By comparison with the deterministic value of the sensor response, the limits of applicability of the deterministic approach are investigated. The results of the presented analysis enable better interpretation of measurement results obtained by using sensors with micro/nanoscale sensing surface, as well as optimization of their design and operating conditions. PB - Elsevier T2 - Materials Today: Proceedings T1 - Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors SP - 16006 EP - 16011 VL - 5 IS - 8, Part 2 DO - 10.1016/j.matpr.2018.05.045 ER -
@article{ author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš", year = "2018", url = "http://www.sciencedirect.com/science/article/pii/S2214785318309167, http://dais.sanu.ac.rs/123456789/4550", abstract = "We investigate the stochastic sensor response in equilibrium, taking into account competitive adsorption and mass transfer of analyte particles in a microfluidic biosensor chamber. After presentation of the stochastic model, we perform the analysis of the equilibrium response expected value as a function of the sensing area and the competitor molecules concentrations. By comparison with the deterministic value of the sensor response, the limits of applicability of the deterministic approach are investigated. The results of the presented analysis enable better interpretation of measurement results obtained by using sensors with micro/nanoscale sensing surface, as well as optimization of their design and operating conditions.", publisher = "Elsevier", journal = "Materials Today: Proceedings", title = "Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors", pages = "16006-16011", volume = "5", number = "8, Part 2", doi = "10.1016/j.matpr.2018.05.045" }
Jokić I, Đurić ZG, Radulović K, Frantlović M. Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors. Materials Today: Proceedings. 2018;5(8, Part 2):16006-16011
Jokić, I., Đurić, Z. G., Radulović, K.,& Frantlović, M. (2018). Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors. Materials Today: ProceedingsElsevier., 5(8, Part 2), 16006-16011. https://doi.org/10.1016/j.matpr.2018.05.045
Jokić Ivana, Đurić Zoran G., Radulović Katarina, Frantlović Miloš, "Deterministic versus Stochastic Analysis of Competitive Adsorption in Equilibrium in Microfluidic Biosensors" 5, no. 8, Part 2 (2018):16006-16011, https://doi.org/10.1016/j.matpr.2018.05.045 .