Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3

2012
Authors
Ajduković, Zorica
Petrović, Milica B.

Ignjatović, Nenad

Savić, Vojin
Mihailović, Dragan
Uskoković, Dragan

Conference object (Published version)
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Increased life expectancy in developed countries leads to an increase in the number of musculoskeletal disorders, such as osteoporosis, oasteoratritis thus compromising good dental treatment. There are many drug delivery systems based on hydroxyapatite used in bone tissue regeneration. Vitamin D3 is osteodiferentiation factor which regulates bone formation by increasing osteoblast differentiation and bone mineralization. The aim of this study is to examine new multifunctional nanoparticulate system for local delivery of active form of vitamin D3 by biochemical blood marker and histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks, which have been implanted biomaterials in the artificial bone defect. Biochemical markers of osteogenesis were statistically significant after only 6 weeks of implantation. ALP activity in bone tissue was showed by histochemical analysis as well as high level reparatory skills. Local realized Vitamin D3 contribute to bone ...formation by increasing osteoblast differentiation and bone mineralization.
Keywords:
hydroxyapatite / nanoparticles / vitamin D3Source:
The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts, 2012, 121-121Publisher:
- Belgrade : Materials Research Society of Serbia
Funding / projects:
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ajduković, Zorica AU - Petrović, Milica B. AU - Ignjatović, Nenad AU - Savić, Vojin AU - Mihailović, Dragan AU - Uskoković, Dragan PY - 2012 UR - https://dais.sanu.ac.rs/123456789/454 AB - Increased life expectancy in developed countries leads to an increase in the number of musculoskeletal disorders, such as osteoporosis, oasteoratritis thus compromising good dental treatment. There are many drug delivery systems based on hydroxyapatite used in bone tissue regeneration. Vitamin D3 is osteodiferentiation factor which regulates bone formation by increasing osteoblast differentiation and bone mineralization. The aim of this study is to examine new multifunctional nanoparticulate system for local delivery of active form of vitamin D3 by biochemical blood marker and histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks, which have been implanted biomaterials in the artificial bone defect. Biochemical markers of osteogenesis were statistically significant after only 6 weeks of implantation. ALP activity in bone tissue was showed by histochemical analysis as well as high level reparatory skills. Local realized Vitamin D3 contribute to bone formation by increasing osteoblast differentiation and bone mineralization. PB - Belgrade : Materials Research Society of Serbia C3 - The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts T1 - Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3 SP - 121 EP - 121 UR - https://hdl.handle.net/21.15107/rcub_dais_454 ER -
@conference{ author = "Ajduković, Zorica and Petrović, Milica B. and Ignjatović, Nenad and Savić, Vojin and Mihailović, Dragan and Uskoković, Dragan", year = "2012", abstract = "Increased life expectancy in developed countries leads to an increase in the number of musculoskeletal disorders, such as osteoporosis, oasteoratritis thus compromising good dental treatment. There are many drug delivery systems based on hydroxyapatite used in bone tissue regeneration. Vitamin D3 is osteodiferentiation factor which regulates bone formation by increasing osteoblast differentiation and bone mineralization. The aim of this study is to examine new multifunctional nanoparticulate system for local delivery of active form of vitamin D3 by biochemical blood marker and histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks, which have been implanted biomaterials in the artificial bone defect. Biochemical markers of osteogenesis were statistically significant after only 6 weeks of implantation. ALP activity in bone tissue was showed by histochemical analysis as well as high level reparatory skills. Local realized Vitamin D3 contribute to bone formation by increasing osteoblast differentiation and bone mineralization.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts", title = "Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3", pages = "121-121", url = "https://hdl.handle.net/21.15107/rcub_dais_454" }
Ajduković, Z., Petrović, M. B., Ignjatović, N., Savić, V., Mihailović, D.,& Uskoković, D.. (2012). Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 121-121. https://hdl.handle.net/21.15107/rcub_dais_454
Ajduković Z, Petrović MB, Ignjatović N, Savić V, Mihailović D, Uskoković D. Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts. 2012;:121-121. https://hdl.handle.net/21.15107/rcub_dais_454 .
Ajduković, Zorica, Petrović, Milica B., Ignjatović, Nenad, Savić, Vojin, Mihailović, Dragan, Uskoković, Dragan, "Regeneration bone tissue by new nanoparticules system based on hydroxiapatite as systems for local delivery of vitamin D3" in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts (2012):121-121, https://hdl.handle.net/21.15107/rcub_dais_454 .