Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
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We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as co...mpact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
Keywords:
Composite hydrogel membrane Crosslinker Ion exchange Diffusion Iontophoresis Drug releaseSource:
Polymer, 2018, 147, 56-66Publisher:
- Elsevier
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
Note:
- Supplementary information: https://hdl.handle.net/21.15107/rcub_dais_3392
- Published version: https://hdl.handle.net/21.15107/rcub_dais_3391
Related info:
- Version of
http://dx.doi.org/10.1016/j.polymer.2018.05.065 - Version of
https://hdl.handle.net/21.15107/rcub_dais_3391 - Referenced by
https://hdl.handle.net/21.15107/rcub_dais_3392
DOI: 10.1016/j.polymer.2018.05.065
ISSN: 0032-3861
WoS: 000436484100007
Scopus: 2-s2.0-85048491046
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Janićijević, Željko AU - Radovanović, Filip PY - 2018 UR - https://dais.sanu.ac.rs/123456789/4526 AB - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs. PB - Elsevier T2 - Polymer T1 - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations SP - 56 EP - 66 VL - 147 DO - 10.1016/j.polymer.2018.05.065 UR - https://hdl.handle.net/21.15107/rcub_dais_4526 ER -
@article{ author = "Janićijević, Željko and Radovanović, Filip", year = "2018", abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.", publisher = "Elsevier", journal = "Polymer", title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations", pages = "56-66", volume = "147", doi = "10.1016/j.polymer.2018.05.065", url = "https://hdl.handle.net/21.15107/rcub_dais_4526" }
Janićijević, Ž.,& Radovanović, F.. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer Elsevier., 147, 56-66. https://doi.org/10.1016/j.polymer.2018.05.065 https://hdl.handle.net/21.15107/rcub_dais_4526
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer. 2018;147:56-66. doi:10.1016/j.polymer.2018.05.065 https://hdl.handle.net/21.15107/rcub_dais_4526 .
Janićijević, Željko, Radovanović, Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" in Polymer, 147 (2018):56-66, https://doi.org/10.1016/j.polymer.2018.05.065 ., https://hdl.handle.net/21.15107/rcub_dais_4526 .