We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as co...mpact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
Keywords:
Composite hydrogel membrane Crosslinker Ion exchange Diffusion Iontophoresis Drug release
TY - JOUR
AU - Janićijević, Željko
AU - Radovanović, Filip
PY - 2018
UR - https://dais.sanu.ac.rs/123456789/4526
AB - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
PB - Elsevier
T2 - Polymer
T1 - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
SP - 56
EP - 66
VL - 147
DO - 10.1016/j.polymer.2018.05.065
UR - https://hdl.handle.net/21.15107/rcub_dais_4526
ER -
@article{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2018",
abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranesperformed by combining photoirradiation with a traditional liquid phase inversion process.Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and theirmicrostructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker wascrucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passiveand iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinkerwere investigated in vitro using methylene blue as a model drug. Passive release kinetics wasdiffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics wasdemonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot ofpromise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.",
publisher = "Elsevier",
journal = "Polymer",
title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations",
pages = "56-66",
volume = "147",
doi = "10.1016/j.polymer.2018.05.065",
url = "https://hdl.handle.net/21.15107/rcub_dais_4526"
}
Janićijević, Ž.,& Radovanović, F.. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer
Elsevier., 147, 56-66.
https://doi.org/10.1016/j.polymer.2018.05.065
https://hdl.handle.net/21.15107/rcub_dais_4526
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer. 2018;147:56-66.
doi:10.1016/j.polymer.2018.05.065
https://hdl.handle.net/21.15107/rcub_dais_4526 .
Janićijević, Željko, Radovanović, Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" in Polymer, 147 (2018):56-66,
https://doi.org/10.1016/j.polymer.2018.05.065 .,
https://hdl.handle.net/21.15107/rcub_dais_4526 .
