Lanthanide doped hydroxyapatite for multimodal imaging
Authors
Dinić, Ivana
Vuković, Marina

Ignjatović, Nenad

Stojanović, Zoran S.

Škapin, Srečo Davor

Veselinović, Ljiljana

Mančić, Lidija

Conference object (Published version)
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Lantanide dual-doped hydroxyapatite (HaP:Ln) is currently the subject of numerous studies in reconstructive medicine. Designed in form of hybrid nanoparticles which have magnetic and luminescent properties HaP:Ln (where Ln=Gd/Eu or Gd/Yb/Tm) is capable to enhance signal detection. Beside it, due biodegradable properties it is suitable for use in bone tissue engineering and target drug delivery. For such a promising approach, doping of a HAp matrix is performed with Gd/Eu and Gd/Yb/Tm during hydrothermal synthesis using EDTA as chelating agent. Morphological and structural characteristics of the particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR) and photoluminescence (PL). The results show that needle-like nano- or micro- particles were obtained in all systems. Their phase composition and uniform distribution of dopants were confirmed by the ...structural refinement of the XRPD data and luminescence response from Eu and Tb (λex = 370, 394 and 977 nm).
Keywords:
lantanide / doping / hydroxyapatite / multimodal imagingSource:
Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018, 2018, 71-71Publisher:
- Belgrade : Serbian Ceramic Society
Funding / projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Dinić, Ivana AU - Vuković, Marina AU - Ignjatović, Nenad AU - Stojanović, Zoran S. AU - Škapin, Srečo Davor AU - Veselinović, Ljiljana AU - Mančić, Lidija PY - 2018 UR - https://dais.sanu.ac.rs/123456789/4118 AB - Lantanide dual-doped hydroxyapatite (HaP:Ln) is currently the subject of numerous studies in reconstructive medicine. Designed in form of hybrid nanoparticles which have magnetic and luminescent properties HaP:Ln (where Ln=Gd/Eu or Gd/Yb/Tm) is capable to enhance signal detection. Beside it, due biodegradable properties it is suitable for use in bone tissue engineering and target drug delivery. For such a promising approach, doping of a HAp matrix is performed with Gd/Eu and Gd/Yb/Tm during hydrothermal synthesis using EDTA as chelating agent. Morphological and structural characteristics of the particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR) and photoluminescence (PL). The results show that needle-like nano- or micro- particles were obtained in all systems. Their phase composition and uniform distribution of dopants were confirmed by the structural refinement of the XRPD data and luminescence response from Eu and Tb (λex = 370, 394 and 977 nm). PB - Belgrade : Serbian Ceramic Society C3 - Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018 T1 - Lanthanide doped hydroxyapatite for multimodal imaging SP - 71 EP - 71 UR - https://hdl.handle.net/21.15107/rcub_dais_4118 ER -
@conference{ author = "Dinić, Ivana and Vuković, Marina and Ignjatović, Nenad and Stojanović, Zoran S. and Škapin, Srečo Davor and Veselinović, Ljiljana and Mančić, Lidija", year = "2018", abstract = "Lantanide dual-doped hydroxyapatite (HaP:Ln) is currently the subject of numerous studies in reconstructive medicine. Designed in form of hybrid nanoparticles which have magnetic and luminescent properties HaP:Ln (where Ln=Gd/Eu or Gd/Yb/Tm) is capable to enhance signal detection. Beside it, due biodegradable properties it is suitable for use in bone tissue engineering and target drug delivery. For such a promising approach, doping of a HAp matrix is performed with Gd/Eu and Gd/Yb/Tm during hydrothermal synthesis using EDTA as chelating agent. Morphological and structural characteristics of the particles were obtained using X-ray powder diffraction (XRPD), scanning and transmission electron microscopy (SEM/TEM), energy dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR) and photoluminescence (PL). The results show that needle-like nano- or micro- particles were obtained in all systems. Their phase composition and uniform distribution of dopants were confirmed by the structural refinement of the XRPD data and luminescence response from Eu and Tb (λex = 370, 394 and 977 nm).", publisher = "Belgrade : Serbian Ceramic Society", journal = "Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018", title = "Lanthanide doped hydroxyapatite for multimodal imaging", pages = "71-71", url = "https://hdl.handle.net/21.15107/rcub_dais_4118" }
Dinić, I., Vuković, M., Ignjatović, N., Stojanović, Z. S., Škapin, S. D., Veselinović, L.,& Mančić, L.. (2018). Lanthanide doped hydroxyapatite for multimodal imaging. in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018 Belgrade : Serbian Ceramic Society., 71-71. https://hdl.handle.net/21.15107/rcub_dais_4118
Dinić I, Vuković M, Ignjatović N, Stojanović ZS, Škapin SD, Veselinović L, Mančić L. Lanthanide doped hydroxyapatite for multimodal imaging. in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018. 2018;:71-71. https://hdl.handle.net/21.15107/rcub_dais_4118 .
Dinić, Ivana, Vuković, Marina, Ignjatović, Nenad, Stojanović, Zoran S., Škapin, Srečo Davor, Veselinović, Ljiljana, Mančić, Lidija, "Lanthanide doped hydroxyapatite for multimodal imaging" in Program and the Book of Abstracts / Serbian Ceramic Society Conference Advanced Ceramics and Application VII : New Frontiers in Multifunctional Material Science and Processing, Serbia, Belgrade, 17-19 September 2018 (2018):71-71, https://hdl.handle.net/21.15107/rcub_dais_4118 .