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Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine

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2018
CH_6__Radiolabele_0AAAF_Ignjatovic_v2.pdf (1.112Mb)
Authors
Vranješ Đurić, Sanja
Ignjatović, Nenad
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Abstract
Nuclear medicine is a branch of medicine that uses radiation to provide infor¬mation about the functioning of a person’s specific tissue/organs or to treat a disease. Radiolabeled nanoparticles (NPs) represent a new class of agents with a great potential for nuclear medicine applications. The key advantage of using radiolabeled NPs is that a very small amount can be used to obtain information of great importance.1 They may be used to detect and characterize disease, to deliver relevant therapeutics, and to monitor the therapeutic effect as well. Furthermore radiotracer-based imaging either using single-photon emission computed tomog¬raphy (SPECT) or positron emission tomography (PET) is particularly suited in the study of pharmacokinetic/pharmacodynamic parameters of nanomaterials and determination of their optimal nanodimensional architecture for tissue/organ re¬generation. Measuring radiation from radioactive tracers attached to NPs has been demonstrated to be a highly sensitive and ...specific method that allows accurate quantification, without limits to tissue penetration in any organ. Nuclear imaging approaches are highly suitable for detection, as they offer a high detection sensitiv¬ity at high temporal and spatial resolutions, requiring a radionuclide concentration of around 10−10 M at the site of interest.Nanoparticulate agents typically demonstrate pharmacokinetic behavior differ¬ent from that of small molecules2 and provide flexible platforms for integration of multiple functional entities, including targeting ligands, multiple types of contrast materials, and/or therapeutics. In contrast to traditional compounds used for radio¬pharmaceutical preparation, nanomaterials have an immense available surface area per unit of volume and tunable optical, electronic, magnetic, and biological proper¬ties. Generally, they can be tailored to meet the needs of specific applications and engineered to have different physicochemical properties that affect in vivo biodis¬tribution: sizes, shapes, chemical compositions, surface chemical characteristics, and hollow or solid structures.3 Efficient diagnosis/radiotherapy is provided through passive targeting based on the enhanced permeability and retention (EPR) effect and/or active targeting through the incorporation of a targeting moiety on an NP. Nontargeted NPs can accumulate in tumors, as the tumor vasculature is usually leaky and without lymphatic drainage. Active targeting is achieved by functionalizing the NPs surface with suitable vectors, including peptides, antibodies, and other biomolecules, which recognize characteristic epitopes at the surface of the diseased cells. Radiolabeled antibodies may effectively target even single cancer cells in circula¬tion5 or small cancer cell clusters,6 thereby enabling a more specific radiation dose delivery, preventing damage to healthy tissues.

Source:
Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture, 2018, 65-92
Publisher:
  • Elsevier
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
Note:
  • This is the peer-reviewed version of the book chapter: Vranješ Đurić, Sanja, and Nenad Ignjatović. 2018. “Subchapter 1.4: Radiolabeled Functional Nanoparticles in Preventive and Regenerative Medicine.” In Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture, 65–92. Elsevier. https://hdl.handle.net/21.15107/rcub_dais_16001.
  • Published version: https://hdl.handle.net/21.15107/rcub_dais_16001

DOI: 10.1016/B978-0-323-48063-5.00001-0

ISBN: 978-0-323-48063-5

Scopus: 2-s2.0-85041104878
[ Google Scholar ]
2
Handle
https://hdl.handle.net/21.15107/rcub_dais_4068
URI
https://dais.sanu.ac.rs/123456789/4068
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CHAP
AU  - Vranješ Đurić, Sanja
AU  - Ignjatović, Nenad
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/4068
AB  - Nuclear medicine is a branch of medicine that uses radiation to provide infor¬mation about the functioning of a person’s specific tissue/organs or to treat a disease. Radiolabeled nanoparticles (NPs) represent a new class of agents with a great potential for nuclear medicine applications. The key advantage of using radiolabeled NPs is that a very small amount can be used to obtain information of great importance.1 They may be used to detect and characterize disease, to deliver relevant therapeutics, and to monitor the therapeutic effect as well. Furthermore radiotracer-based imaging either using single-photon emission computed tomog¬raphy (SPECT) or positron emission tomography (PET) is particularly suited in the study of pharmacokinetic/pharmacodynamic parameters of nanomaterials and determination of their optimal nanodimensional architecture for tissue/organ re¬generation. Measuring radiation from radioactive tracers attached to NPs has been demonstrated to be a highly sensitive and specific method that allows accurate quantification, without limits to tissue penetration in any organ. Nuclear imaging approaches are highly suitable for detection, as they offer a high detection sensitiv¬ity at high temporal and spatial resolutions, requiring a radionuclide concentration of around 10−10 M at the site of interest.Nanoparticulate agents typically demonstrate pharmacokinetic behavior differ¬ent from that of small molecules2 and provide flexible platforms for integration of multiple functional entities, including targeting ligands, multiple types of contrast materials, and/or therapeutics. In contrast to traditional compounds used for radio¬pharmaceutical preparation, nanomaterials have an immense available surface area per unit of volume and tunable optical, electronic, magnetic, and biological proper¬ties. Generally, they can be tailored to meet the needs of specific applications and engineered to have different physicochemical properties that affect in vivo biodis¬tribution: sizes, shapes, chemical compositions, surface chemical characteristics, and hollow or solid structures.3 Efficient diagnosis/radiotherapy is provided through passive targeting based on the enhanced permeability and retention (EPR) effect and/or active targeting through the incorporation of a targeting moiety on an NP. Nontargeted NPs can accumulate in tumors, as the tumor vasculature is usually leaky and without lymphatic drainage. Active targeting is achieved by functionalizing the NPs surface with suitable vectors, including peptides, antibodies, and other biomolecules, which recognize characteristic epitopes at the surface of the diseased cells. Radiolabeled antibodies may effectively target even single cancer cells in circula¬tion5 or small cancer cell clusters,6 thereby enabling a more specific radiation dose delivery, preventing damage to healthy tissues.
PB  - Elsevier
T2  - Nanotechnologies in Preventive and Regenerative Medicine:  An Emerging Big Picture
T1  - Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine
SP  - 65
EP  - 92
DO  - 10.1016/B978-0-323-48063-5.00001-0
UR  - https://hdl.handle.net/21.15107/rcub_dais_4068
ER  - 
@inbook{
author = "Vranješ Đurić, Sanja and Ignjatović, Nenad",
year = "2018",
abstract = "Nuclear medicine is a branch of medicine that uses radiation to provide infor¬mation about the functioning of a person’s specific tissue/organs or to treat a disease. Radiolabeled nanoparticles (NPs) represent a new class of agents with a great potential for nuclear medicine applications. The key advantage of using radiolabeled NPs is that a very small amount can be used to obtain information of great importance.1 They may be used to detect and characterize disease, to deliver relevant therapeutics, and to monitor the therapeutic effect as well. Furthermore radiotracer-based imaging either using single-photon emission computed tomog¬raphy (SPECT) or positron emission tomography (PET) is particularly suited in the study of pharmacokinetic/pharmacodynamic parameters of nanomaterials and determination of their optimal nanodimensional architecture for tissue/organ re¬generation. Measuring radiation from radioactive tracers attached to NPs has been demonstrated to be a highly sensitive and specific method that allows accurate quantification, without limits to tissue penetration in any organ. Nuclear imaging approaches are highly suitable for detection, as they offer a high detection sensitiv¬ity at high temporal and spatial resolutions, requiring a radionuclide concentration of around 10−10 M at the site of interest.Nanoparticulate agents typically demonstrate pharmacokinetic behavior differ¬ent from that of small molecules2 and provide flexible platforms for integration of multiple functional entities, including targeting ligands, multiple types of contrast materials, and/or therapeutics. In contrast to traditional compounds used for radio¬pharmaceutical preparation, nanomaterials have an immense available surface area per unit of volume and tunable optical, electronic, magnetic, and biological proper¬ties. Generally, they can be tailored to meet the needs of specific applications and engineered to have different physicochemical properties that affect in vivo biodis¬tribution: sizes, shapes, chemical compositions, surface chemical characteristics, and hollow or solid structures.3 Efficient diagnosis/radiotherapy is provided through passive targeting based on the enhanced permeability and retention (EPR) effect and/or active targeting through the incorporation of a targeting moiety on an NP. Nontargeted NPs can accumulate in tumors, as the tumor vasculature is usually leaky and without lymphatic drainage. Active targeting is achieved by functionalizing the NPs surface with suitable vectors, including peptides, antibodies, and other biomolecules, which recognize characteristic epitopes at the surface of the diseased cells. Radiolabeled antibodies may effectively target even single cancer cells in circula¬tion5 or small cancer cell clusters,6 thereby enabling a more specific radiation dose delivery, preventing damage to healthy tissues.",
publisher = "Elsevier",
journal = "Nanotechnologies in Preventive and Regenerative Medicine:  An Emerging Big Picture",
booktitle = "Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine",
pages = "65-92",
doi = "10.1016/B978-0-323-48063-5.00001-0",
url = "https://hdl.handle.net/21.15107/rcub_dais_4068"
}
Vranješ Đurić, S.,& Ignjatović, N.. (2018). Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine. in Nanotechnologies in Preventive and Regenerative Medicine:  An Emerging Big Picture
Elsevier., 65-92.
https://doi.org/10.1016/B978-0-323-48063-5.00001-0
https://hdl.handle.net/21.15107/rcub_dais_4068
Vranješ Đurić S, Ignjatović N. Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine. in Nanotechnologies in Preventive and Regenerative Medicine:  An Emerging Big Picture. 2018;:65-92.
doi:10.1016/B978-0-323-48063-5.00001-0
https://hdl.handle.net/21.15107/rcub_dais_4068 .
Vranješ Đurić, Sanja, Ignjatović, Nenad, "Subchapter 1.4: Radiolabeled functional nanoparticles in preventive and regenerative medicine" in Nanotechnologies in Preventive and Regenerative Medicine:  An Emerging Big Picture (2018):65-92,
https://doi.org/10.1016/B978-0-323-48063-5.00001-0 .,
https://hdl.handle.net/21.15107/rcub_dais_4068 .

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