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Routes and pathways to small particles based on hydroxyapatite

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2013
390.pdf (50.60Kb)
Authors
Ignjatović, Nenad
Vranješ Đurić, Sanja
Mitić, Žarko
Janković, Drina
Uskoković, Dragan
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Abstract
Nanoparticles based on hydroxyapatite (NPs) have many useful physicochemical and biological properties, such as easy preparation and modification, as well as biocompatibility, which make them suitable for transport and unloading of various pharmaceuticals. Hydroxyapatite nanoparticles coated with bioresorbable polymers have been successfully used as carriers of antibiotics and vitamins in bone tissue engineering. In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite and hydroxyapatite coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. The influence of the processing technique on the structure and characteristics of the obtained particles was studied by X-ray diffraction (XRD), particle size distribution analysis (PSD), Fourier transform infrared spectroscopy (FTIR), zeta potential analysis (ZP) and scanning electronic microscopy (SEM). In applied research, an appropriate radioisotope (Iodine-125) was selected and it was ...used to label particles. The in vivo biodistribution of 125I-labeled particles were studied in healthy Wistar rats following intravenous administration. The XRD, FT-IR and ZP analyses have confirmed that the hydroxyapatite particles with d50=72 nm are coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. 125I-labeled particles showed completely different behaviour in vivo: hydroxyapatite particles have the highest liver accumulation 10 min after injection but rapid excretion from the body without residual radioactivity 24 hours after injection; chitozan coated hydroxyapatite particles have the highest accumulation in the liver 10 min after injection with considerable amount (almost 50 %) retained 24 hours later; hydroxyapatite particles coated with the chitosanpoly-D,L-lactide-co-glycolide polymer blend have the highest uptake in the lungs 10 minutes after injection and moderate retention in the same organ 24 hours later.

Keywords:
hydorxyapatite / particles / chitosan / chitosan-poly(D,L)-lactide-co-glycolide
Source:
The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts, 2013, 7-7
Publisher:
  • Belgrade : Materials Research Society of Serbia
Projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
[ Google Scholar ]
URI
http://dais.sanu.ac.rs/123456789/393
Collections
  • ITN SANU - Opšta kolekcija / ITS SASA - General collection
Institution
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CONF
AU  - Ignjatović, Nenad
AU  - Vranješ Đurić, Sanja
AU  - Mitić, Žarko
AU  - Janković, Drina
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/393
AB  - Nanoparticles based on hydroxyapatite (NPs) have many useful physicochemical and biological
properties, such as easy preparation and modification, as well as biocompatibility, which make them suitable for transport and unloading of various pharmaceuticals. Hydroxyapatite
nanoparticles coated with bioresorbable polymers have been successfully used as carriers of
antibiotics and vitamins in bone tissue engineering. In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite and hydroxyapatite coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. The influence of the processing technique on the structure and characteristics of the obtained particles was studied by X-ray diffraction (XRD), particle size distribution analysis (PSD), Fourier transform infrared spectroscopy (FTIR), zeta potential analysis (ZP) and scanning electronic microscopy (SEM). In applied research, an appropriate radioisotope (Iodine-125) was selected and it was used to label particles. The in vivo biodistribution of 125I-labeled particles were studied in healthy Wistar rats following intravenous administration. The XRD, FT-IR and ZP analyses have confirmed that the hydroxyapatite particles with d50=72 nm are coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. 125I-labeled particles showed completely different behaviour in vivo: hydroxyapatite particles have the highest liver accumulation 10 min after injection but rapid excretion from the body without residual radioactivity 24 hours after injection; chitozan coated hydroxyapatite particles have the highest accumulation in the liver 10 min after injection with considerable amount (almost 50 %) retained 24 hours later; hydroxyapatite particles coated with the chitosanpoly-D,L-lactide-co-glycolide polymer blend have the highest uptake in the lungs 10 minutes after injection and moderate retention in the same organ 24 hours later.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
T1  - Routes and pathways to small particles based on hydroxyapatite
SP  - 7
EP  - 7
ER  - 
@conference{
author = "Ignjatović, Nenad and Vranješ Đurić, Sanja and Mitić, Žarko and Janković, Drina and Uskoković, Dragan",
year = "2013",
url = "http://dais.sanu.ac.rs/123456789/393",
abstract = "Nanoparticles based on hydroxyapatite (NPs) have many useful physicochemical and biological
properties, such as easy preparation and modification, as well as biocompatibility, which make them suitable for transport and unloading of various pharmaceuticals. Hydroxyapatite
nanoparticles coated with bioresorbable polymers have been successfully used as carriers of
antibiotics and vitamins in bone tissue engineering. In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite and hydroxyapatite coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. The influence of the processing technique on the structure and characteristics of the obtained particles was studied by X-ray diffraction (XRD), particle size distribution analysis (PSD), Fourier transform infrared spectroscopy (FTIR), zeta potential analysis (ZP) and scanning electronic microscopy (SEM). In applied research, an appropriate radioisotope (Iodine-125) was selected and it was used to label particles. The in vivo biodistribution of 125I-labeled particles were studied in healthy Wistar rats following intravenous administration. The XRD, FT-IR and ZP analyses have confirmed that the hydroxyapatite particles with d50=72 nm are coated with chitosan and the chitosan-poly-D,L-lactide-co-glycolide polymer blend. 125I-labeled particles showed completely different behaviour in vivo: hydroxyapatite particles have the highest liver accumulation 10 min after injection but rapid excretion from the body without residual radioactivity 24 hours after injection; chitozan coated hydroxyapatite particles have the highest accumulation in the liver 10 min after injection with considerable amount (almost 50 %) retained 24 hours later; hydroxyapatite particles coated with the chitosanpoly-D,L-lactide-co-glycolide polymer blend have the highest uptake in the lungs 10 minutes after injection and moderate retention in the same organ 24 hours later.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts",
title = "Routes and pathways to small particles based on hydroxyapatite",
pages = "7-7"
}
Ignjatović N, Vranješ Đurić S, Mitić Ž, Janković D, Uskoković D. Routes and pathways to small particles based on hydroxyapatite. The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:7-7
Ignjatović, N., Vranješ Đurić, S., Mitić, Ž., Janković, D.,& Uskoković, D. (2013). Routes and pathways to small particles based on hydroxyapatite.
The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of AbstractsBelgrade : Materials Research Society of Serbia., null, 7-7. 
Ignjatović Nenad, Vranješ Đurić Sanja, Mitić Žarko, Janković Drina, Uskoković Dragan, "Routes and pathways to small particles based on hydroxyapatite" null (2013):7-7

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