One-pot synthesis of biocompatible NaYF4:Yb,Er nanoparticles for cell labeling
Conference object (Published version)
MetadataShow full item record
In modern medical research, great attention has been focused to the development of the new biomarkers which include up-converting nanoparticles (UCNPs). Their optical response is triggered by NIR radiation that achieves deeper tissue penetration when compared with traditionally used fluorophores. In this work, biocompatible NaYF4: Yb, Er nanoparticles were synthesized by polymer assisted one-pot solvothermal processing using chitosan or poly(lacticco- glycolic acid). X-ray powder diffraction and electron microscopy results revealed differences in crystal arrangement and morphology of the as-synthesized particles. Fourier transform infrared spectroscopy confirmed the presence of corresponding polymers moiety on UCNPs surface providing their biocompatibility and low cytotoxicity towards human gingival fibroblasts (HFG). As a consequence of efficient up-conversion, prominent green emission (between 512-533nm and between 533-560nm) as well as red emission (630-690nm) were recorded in the p...articles photoluminescence spectra, and these are applied further in the visualization of the HFG using the laser scanning microscopy with a NIR laser source.
Keywords:up-converting nanoparticles / NaYF4:Yb,Er / cell labelling / nanoparticles
Source:Programme and The Book of Abstracts / Twentieth Annual Conference YUCOMAT 2018, Herceg Novi, September 3-7, 2018, 2018, 116-116
- Belgrade : Materials Research Society of Serbia
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)