Improvement of solubility of disperse materials by the means of the mechanochemical treatment
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The solubility of drug is very important factor that determines its applicability, since solubility may act as rate-limiting step in absorption and therefore may affect the bioavailability of the drug. More than 40% of potential drug products suffer from poor water solubility which frequently results in potentially important products not reaching the market or not achieving their full potential. In this work, an effort will be invested in order to improve solubility of verapamil hydrochloride by the means of mechanochemical treatment. Influence of mechanochemical parameters and surfactants on the physicochemical properties will be examined using a XRD, FE SEM technique and Malvern’s Master Sizer instrument for particle size distribution. Finally, solubility of verapamil hydrochloride will be correlated with the particle size, structural and morphological characteristics of the drug via UV-VIS Cintra 101 spectrometer.
Keywords:
mechanochemical treatment / solubility / verapamil hydrochlorideSource:
Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010, 2010, 92-92Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Makević, Sonja AU - Stanković, Ana AU - Uskoković, Dragan PY - 2010 UR - https://dais.sanu.ac.rs/123456789/3593 AB - The solubility of drug is very important factor that determines its applicability, since solubility may act as rate-limiting step in absorption and therefore may affect the bioavailability of the drug. More than 40% of potential drug products suffer from poor water solubility which frequently results in potentially important products not reaching the market or not achieving their full potential. In this work, an effort will be invested in order to improve solubility of verapamil hydrochloride by the means of mechanochemical treatment. Influence of mechanochemical parameters and surfactants on the physicochemical properties will be examined using a XRD, FE SEM technique and Malvern’s Master Sizer instrument for particle size distribution. Finally, solubility of verapamil hydrochloride will be correlated with the particle size, structural and morphological characteristics of the drug via UV-VIS Cintra 101 spectrometer. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 T1 - Improvement of solubility of disperse materials by the means of the mechanochemical treatment SP - 92 EP - 92 UR - https://hdl.handle.net/21.15107/rcub_dais_3593 ER -
@conference{ author = "Makević, Sonja and Stanković, Ana and Uskoković, Dragan", year = "2010", abstract = "The solubility of drug is very important factor that determines its applicability, since solubility may act as rate-limiting step in absorption and therefore may affect the bioavailability of the drug. More than 40% of potential drug products suffer from poor water solubility which frequently results in potentially important products not reaching the market or not achieving their full potential. In this work, an effort will be invested in order to improve solubility of verapamil hydrochloride by the means of mechanochemical treatment. Influence of mechanochemical parameters and surfactants on the physicochemical properties will be examined using a XRD, FE SEM technique and Malvern’s Master Sizer instrument for particle size distribution. Finally, solubility of verapamil hydrochloride will be correlated with the particle size, structural and morphological characteristics of the drug via UV-VIS Cintra 101 spectrometer.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010", title = "Improvement of solubility of disperse materials by the means of the mechanochemical treatment", pages = "92-92", url = "https://hdl.handle.net/21.15107/rcub_dais_3593" }
Makević, S., Stanković, A.,& Uskoković, D.. (2010). Improvement of solubility of disperse materials by the means of the mechanochemical treatment. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 Belgrade : Institute of Technical Sciences of SASA., 92-92. https://hdl.handle.net/21.15107/rcub_dais_3593
Makević S, Stanković A, Uskoković D. Improvement of solubility of disperse materials by the means of the mechanochemical treatment. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010. 2010;:92-92. https://hdl.handle.net/21.15107/rcub_dais_3593 .
Makević, Sonja, Stanković, Ana, Uskoković, Dragan, "Improvement of solubility of disperse materials by the means of the mechanochemical treatment" in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 (2010):92-92, https://hdl.handle.net/21.15107/rcub_dais_3593 .