Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers
Abstract
Nanocrystalline calcium phosphates (NC CP) are suitable for the synthesis of CP/bioresorbable polymer composite biomaterials for the application in bone engineering. There are different forms of NC CP/ bioresorbable polymers composite biomaterials. Calcium phosphate was synthesised in highly NC form. A NC calcium phosphate/ poly-DL-lactide-co-glycolide (CP/DLPLG) composite biomaterial in filler forms was synthesised in the shape of spherical granules (150-200 μm in diameter) and nanoparticles (30-40 nm in diameter). Each CP granule or nanoparticle was coated with amorphous DLPLG polymer. Using NC and nanosized CP/DLPLG composite materials, an injectable composite biomaterial was prepared. By hot pressing of highly porous NC CP/ bioresorbable polymer composite biomaterials at the polymer's melting temperature, blocks were obtained with relatively uniform distribution of phases. Designing of the properties of CP/bioresorbable polymers composite biomaterial block was provided by combining... high pressure, temperature and time. © 2008 Institute of Materials, Minerals and Mining.
Keywords:
composite biomaterials / injectable paste / nanocrystalline calcium phosphate / resorbable polymerSource:
Advances in Applied Ceramics, 2008, 107, 3, 142-147Publisher:
- Taylor & Francis
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1179/174367608X263421
ISSN: 1743-6753 (Print); 1743-6761
WoS: 000258137000004
Scopus: 2-s2.0-50349087679
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2008 UR - https://dais.sanu.ac.rs/123456789/3581 AB - Nanocrystalline calcium phosphates (NC CP) are suitable for the synthesis of CP/bioresorbable polymer composite biomaterials for the application in bone engineering. There are different forms of NC CP/ bioresorbable polymers composite biomaterials. Calcium phosphate was synthesised in highly NC form. A NC calcium phosphate/ poly-DL-lactide-co-glycolide (CP/DLPLG) composite biomaterial in filler forms was synthesised in the shape of spherical granules (150-200 μm in diameter) and nanoparticles (30-40 nm in diameter). Each CP granule or nanoparticle was coated with amorphous DLPLG polymer. Using NC and nanosized CP/DLPLG composite materials, an injectable composite biomaterial was prepared. By hot pressing of highly porous NC CP/ bioresorbable polymer composite biomaterials at the polymer's melting temperature, blocks were obtained with relatively uniform distribution of phases. Designing of the properties of CP/bioresorbable polymers composite biomaterial block was provided by combining high pressure, temperature and time. © 2008 Institute of Materials, Minerals and Mining. PB - Taylor & Francis T2 - Advances in Applied Ceramics T1 - Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers SP - 142 EP - 147 VL - 107 IS - 3 DO - 10.1179/174367608X263421 UR - https://hdl.handle.net/21.15107/rcub_dais_3581 ER -
@article{ author = "Ignjatović, Nenad and Uskoković, Dragan", year = "2008", abstract = "Nanocrystalline calcium phosphates (NC CP) are suitable for the synthesis of CP/bioresorbable polymer composite biomaterials for the application in bone engineering. There are different forms of NC CP/ bioresorbable polymers composite biomaterials. Calcium phosphate was synthesised in highly NC form. A NC calcium phosphate/ poly-DL-lactide-co-glycolide (CP/DLPLG) composite biomaterial in filler forms was synthesised in the shape of spherical granules (150-200 μm in diameter) and nanoparticles (30-40 nm in diameter). Each CP granule or nanoparticle was coated with amorphous DLPLG polymer. Using NC and nanosized CP/DLPLG composite materials, an injectable composite biomaterial was prepared. By hot pressing of highly porous NC CP/ bioresorbable polymer composite biomaterials at the polymer's melting temperature, blocks were obtained with relatively uniform distribution of phases. Designing of the properties of CP/bioresorbable polymers composite biomaterial block was provided by combining high pressure, temperature and time. © 2008 Institute of Materials, Minerals and Mining.", publisher = "Taylor & Francis", journal = "Advances in Applied Ceramics", title = "Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers", pages = "142-147", volume = "107", number = "3", doi = "10.1179/174367608X263421", url = "https://hdl.handle.net/21.15107/rcub_dais_3581" }
Ignjatović, N.,& Uskoković, D.. (2008). Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers. in Advances in Applied Ceramics Taylor & Francis., 107(3), 142-147. https://doi.org/10.1179/174367608X263421 https://hdl.handle.net/21.15107/rcub_dais_3581
Ignjatović N, Uskoković D. Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers. in Advances in Applied Ceramics. 2008;107(3):142-147. doi:10.1179/174367608X263421 https://hdl.handle.net/21.15107/rcub_dais_3581 .
Ignjatović, Nenad, Uskoković, Dragan, "Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers" in Advances in Applied Ceramics, 107, no. 3 (2008):142-147, https://doi.org/10.1179/174367608X263421 ., https://hdl.handle.net/21.15107/rcub_dais_3581 .