Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid
Abstract
Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron ...Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved.
Keywords:
drug delivery / folic acid / IR / nanoparticles / poly(DL-lactide-co-glycolide) / SEM / stereological analysis / UV-Vis / zeta potential measurementsSource:
Journal of Biomedical Nanotechnology, 2008, 4, 3, 349-358Publisher:
- American Scientific Publishers
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-MESTD-MPN2006-2010-142006)
DOI: 10.1166/jbn.2008.321
ISSN: 1550-7033
WoS: 000260776500014
Scopus: 2-s2.0-58149196373
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Radulović, Aleksandra AU - Jordović, Branka AU - Uskoković, Dragan PY - 2008 UR - https://dais.sanu.ac.rs/123456789/3574 AB - Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved. PB - American Scientific Publishers T2 - Journal of Biomedical Nanotechnology T1 - Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid SP - 349 EP - 358 VL - 4 IS - 3 DO - 10.1166/jbn.2008.321 UR - https://hdl.handle.net/21.15107/rcub_dais_3574 ER -
@article{ author = "Stevanović, Magdalena and Radulović, Aleksandra and Jordović, Branka and Uskoković, Dragan", year = "2008", abstract = "Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved.", publisher = "American Scientific Publishers", journal = "Journal of Biomedical Nanotechnology", title = "Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid", pages = "349-358", volume = "4", number = "3", doi = "10.1166/jbn.2008.321", url = "https://hdl.handle.net/21.15107/rcub_dais_3574" }
Stevanović, M., Radulović, A., Jordović, B.,& Uskoković, D.. (2008). Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid. in Journal of Biomedical Nanotechnology American Scientific Publishers., 4(3), 349-358. https://doi.org/10.1166/jbn.2008.321 https://hdl.handle.net/21.15107/rcub_dais_3574
Stevanović M, Radulović A, Jordović B, Uskoković D. Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid. in Journal of Biomedical Nanotechnology. 2008;4(3):349-358. doi:10.1166/jbn.2008.321 https://hdl.handle.net/21.15107/rcub_dais_3574 .
Stevanović, Magdalena, Radulović, Aleksandra, Jordović, Branka, Uskoković, Dragan, "Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid" in Journal of Biomedical Nanotechnology, 4, no. 3 (2008):349-358, https://doi.org/10.1166/jbn.2008.321 ., https://hdl.handle.net/21.15107/rcub_dais_3574 .