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TY - JOUR
AU - Stevanović, Magdalena
AU - Radulović, Aleksandra
AU - Jordović, Branka
AU - Uskoković, Dragan
PY - 2008
UR - https://dais.sanu.ac.rs/123456789/3574
AB - Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved.
PB - American Scientific Publishers
T2 - Journal of Biomedical Nanotechnology
T1 - Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid
SP - 349
EP - 358
VL - 4
IS - 3
DO - 10.1166/jbn.2008.321
UR - https://hdl.handle.net/21.15107/rcub_dais_3574
ER -
@article{
author = "Stevanović, Magdalena and Radulović, Aleksandra and Jordović, Branka and Uskoković, Dragan",
year = "2008",
abstract = "Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis. Copyright © 2008 American Scientific Publishers All rights reserved.",
publisher = "American Scientific Publishers",
journal = "Journal of Biomedical Nanotechnology",
title = "Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid",
pages = "349-358",
volume = "4",
number = "3",
doi = "10.1166/jbn.2008.321",
url = "https://hdl.handle.net/21.15107/rcub_dais_3574"
}
Stevanović, M., Radulović, A., Jordović, B.,& Uskoković, D.. (2008). Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid. in Journal of Biomedical Nanotechnology
American Scientific Publishers., 4(3), 349-358.
https://doi.org/10.1166/jbn.2008.321
https://hdl.handle.net/21.15107/rcub_dais_3574
Stevanović M, Radulović A, Jordović B, Uskoković D. Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid. in Journal of Biomedical Nanotechnology. 2008;4(3):349-358.
doi:10.1166/jbn.2008.321
https://hdl.handle.net/21.15107/rcub_dais_3574 .
Stevanović, Magdalena, Radulović, Aleksandra, Jordović, Branka, Uskoković, Dragan, "Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid" in Journal of Biomedical Nanotechnology, 4, no. 3 (2008):349-358,
https://doi.org/10.1166/jbn.2008.321 .,
https://hdl.handle.net/21.15107/rcub_dais_3574 .
