Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process
Abstract
Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors.
Keywords:
degradation / DLPLG nanospheres / DLPLG/ascorbic acid nanoparticles / SEM / UVSource:
Journal of Microscopy, 2008, 232, 3, 511-516Publisher:
- Wiley
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1111/j.1365-2818.2008.02150.x
ISSN: 0022-2720
WoS: 000261253200034
Scopus: 2-s2.0-57449095658
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Jordović, Branka AU - Uskoković, Dragan PY - 2008 UR - https://dais.sanu.ac.rs/123456789/3569 AB - Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors. PB - Wiley T2 - Journal of Microscopy T1 - Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process SP - 511 EP - 516 VL - 232 IS - 3 DO - 10.1111/j.1365-2818.2008.02150.x UR - https://hdl.handle.net/21.15107/rcub_dais_3569 ER -
@article{ author = "Stevanović, Magdalena and Jordović, Branka and Uskoković, Dragan", year = "2008", abstract = "Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors.", publisher = "Wiley", journal = "Journal of Microscopy", title = "Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process", pages = "511-516", volume = "232", number = "3", doi = "10.1111/j.1365-2818.2008.02150.x", url = "https://hdl.handle.net/21.15107/rcub_dais_3569" }
Stevanović, M., Jordović, B.,& Uskoković, D.. (2008). Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process. in Journal of Microscopy Wiley., 232(3), 511-516. https://doi.org/10.1111/j.1365-2818.2008.02150.x https://hdl.handle.net/21.15107/rcub_dais_3569
Stevanović M, Jordović B, Uskoković D. Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process. in Journal of Microscopy. 2008;232(3):511-516. doi:10.1111/j.1365-2818.2008.02150.x https://hdl.handle.net/21.15107/rcub_dais_3569 .
Stevanović, Magdalena, Jordović, Branka, Uskoković, Dragan, "Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process" in Journal of Microscopy, 232, no. 3 (2008):511-516, https://doi.org/10.1111/j.1365-2818.2008.02150.x ., https://hdl.handle.net/21.15107/rcub_dais_3569 .