Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process

Stevanović, Magdalena; Jordović, Branka; Uskoković, Dragan

doi:10.1111/j.1365-2818.2008.02150.x

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2008

Authors

Stevanović, Magdalena

Jordović, Branka
Uskoković, Dragan

Article (Published version)

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Abstract

Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors.

Keywords:

degradation / DLPLG nanospheres / DLPLG/ascorbic acid nanoparticles / SEM / UV

Source:
Journal of Microscopy, 2008, 232, 3, 511-516

Publisher:

Wiley

Funding / projects:

Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)

DOI: 10.1111/j.1365-2818.2008.02150.x

ISSN: 0022-2720

WoS: 000261253200034

Scopus: 2-s2.0-57449095658

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	3
	2

TY  - JOUR
AU  - Stevanović, Magdalena
AU  - Jordović, Branka
AU  - Uskoković, Dragan
PY  - 2008
UR  - https://dais.sanu.ac.rs/123456789/3569
AB  - Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors.
PB  - Wiley
T2  - Journal of Microscopy
T1  - Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process
SP  - 511
EP  - 516
VL  - 232
IS  - 3
DO  - 10.1111/j.1365-2818.2008.02150.x
UR  - https://hdl.handle.net/21.15107/rcub_dais_3569
ER  -

@article{
author = "Stevanović, Magdalena and Jordović, Branka and Uskoković, Dragan",
year = "2008",
abstract = "Poly(dl-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(dl-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy. © 2008 The Authors.",
publisher = "Wiley",
journal = "Journal of Microscopy",
title = "Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process",
pages = "511-516",
volume = "232",
number = "3",
doi = "10.1111/j.1365-2818.2008.02150.x",
url = "https://hdl.handle.net/21.15107/rcub_dais_3569"
}

Stevanović, M., Jordović, B.,& Uskoković, D.. (2008). Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process. in Journal of Microscopy
Wiley., 232(3), 511-516.
https://doi.org/10.1111/j.1365-2818.2008.02150.x
https://hdl.handle.net/21.15107/rcub_dais_3569

Stevanović M, Jordović B, Uskoković D. Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process. in Journal of Microscopy. 2008;232(3):511-516.
doi:10.1111/j.1365-2818.2008.02150.x
https://hdl.handle.net/21.15107/rcub_dais_3569 .

Stevanović, Magdalena, Jordović, Branka, Uskoković, Dragan, "Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process" in Journal of Microscopy, 232, no. 3 (2008):511-516,
https://doi.org/10.1111/j.1365-2818.2008.02150.x .,
https://hdl.handle.net/21.15107/rcub_dais_3569 .